1-(difluoroMethyl)-4-iodo-1H-pyrazole

Base Information

• Chemical Name: 1-(difluoroMethyl)-4-iodo-1H-pyrazole
• CAS No.: 1041205-43-9
• Molecular Formula: C4H3F2IN2
• Molecular Weight: 243.983
• Hs Code.: 2933199090
• Mol file: 1041205-43-9.mol

Synonyms:1-(difluoroMethyl)-4-iodo-1H-pyrazole

Chemical Property of 1-(difluoroMethyl)-4-iodo-1H-pyrazole

Chemical Property:

• PSA: 17.82000
• LogP: 1.88280
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

1-(Difluoromethyl)-4-iodo-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(Difluoromethyl)-4-iodo-1H-pyrazole is used in the preparation of pyrazole compounds as IRAK inhibitors for treating autoimmune diseases, inflammatory diseases and cancer

Technology Process of 1-(difluoroMethyl)-4-iodo-1H-pyrazole

There total 2 articles about 1-(difluoroMethyl)-4-iodo-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4-iodopyrazole (3469-69-0) + sodium chlorodifluoroacetate (1895-39-2) → 1-(difluoromethyl)-4-iodo-1H-pyrazole (1041205-43-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield:

4-iodopyrazole (3469-69-0) + Difluoroacetic acid (381-73-7) → 1-(difluoromethyl)-4-iodo-1H-pyrazole (1041205-43-9)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

1-(difluoromethyl)-4-iodo-1H-pyrazole (1041205-43-9) → 4-bromo-3,5-diethoxybenzoic acid (363166-41-0)

Guidance literature:

1-(difluoromethyl)-4-iodo-1H-pyrazole; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

upstream raw materials:

4-iodopyrazole

Difluoroacetic acid

sodium chlorodifluoroacetate

Downstream raw materials:

4-bromo-3,5-diethoxybenzoic acid

Refernces

• 1、 -. "SPIROCHROMANON DERIVATIVES". Page/Page column 152. . Retrieved 2008/12/07.