2-CarbaMoyl-3-hydroxy-1,4-naphthoquinone

Base Information

• Chemical Name: 2-CarbaMoyl-3-hydroxy-1,4-naphthoquinone
• CAS No.: 103646-20-4
• Molecular Formula: C11H7NO4
• Molecular Weight: 217.17758
• Mol file: 103646-20-4.mol

Synonyms:2-CarbaMoyl-3-hydroxy-1,4-naphthoquinone;1,4-Dihydro-3-hydroxy-1,4-dioxo-2-naphthalenecarboxamide

Chemical Property of 2-CarbaMoyl-3-hydroxy-1,4-naphthoquinone

Chemical Property:

• PSA: 97.46000
• LogP: 1.06330

Purity/Quality:

98%Min ^*data from raw suppliers

2-Carbamoyl-3-hydroxy-1,4-naphthoquinone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CarbaMoyl-3-hydroxy-1,4-naphthoquinone

There total 4 articles about 2-CarbaMoyl-3-hydroxy-1,4-naphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-Carbamoyl-3-methoxy-1,4-naphthoquinone (144258-80-0) → 2-Carbamoyl-3-hydroxy-1,4-naphthoquinone (103646-20-4)

Guidance literature:

With boron trichloride; In dichloromethane; at -78 ℃; for 24h;

DOI:10.1016/0031-9422(92)83662-I

Reference yield:

2-Carbomethoxy-3-methoxy-1,4-naphthoquinone (144258-81-1) → 2-Carbamoyl-3-hydroxy-1,4-naphthoquinone (103646-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NH₄OH, NH₄Cl / methanol / 2 h / Ambient temperature

2: 64 percent / BCl₃ / CH₂Cl₂ / 24 h / -78 °C

With ammonium hydroxide; boron trichloride; ammonium chloride; In methanol; dichloromethane;

DOI:10.1016/0031-9422(92)83662-I

Reference yield:

4-dimethylamino-1,3-dihydroxy-[2]naphthoic acid amide; hydrochloride (109401-40-3) → 2-Carbamoyl-3-hydroxy-1,4-naphthoquinone (103646-20-4)

Guidance literature:

With air; water;

upstream raw materials:

4-dimethylamino-1,3-dihydroxy-[2]naphthoic acid amide; hydrochloride

2-Carbamoyl-3-methoxy-1,4-naphthoquinone

2-Carbomethoxy-3-methoxy-1,4-naphthoquinone

Refernces