Pronestyl

Base Information

• Chemical Name: Pronestyl
• CAS No.: 614-39-1
• Molecular Formula: C13H22ClN3O
• Molecular Weight: 271.79
• Hs Code.: 29242990
• Mol file: 614-39-1.mol

Synonyms:Amide, Procaine;Apo-Procainamide;Biocoryl;Hydrochloride, Procainamide;Novocainamide;Novocamid;Procainamide;Procainamide Hydrochloride;Procaine Amide;Procamide;Procan;Procan SR;Procanbid;Pronestyl;Rhythmin

Chemical Property of Pronestyl

Chemical Property:

• Appearance/Colour: White to slightly yellow powder
• Melting Point: 165-168 °C
• Refractive Index: 1.6330 (estimate)
• Boiling Point: 421.8 °C at 760 mmHg
• Flash Point: 208.9 °C
• PSA: 58.36000
• Density: 1.2027 (rough estimate)
• LogP: 3.11450
• Storage Temp.: 2-8°C
• Sensitive.: Light Sensitive/Air Sensitive
• Solubility.: H2O: soluble1g/10 mL, clear, greenish-yellow
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 271.1451400
• Heavy Atom Count: 18
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

Procainamide Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.[Cl-]
• Description: Procainamide (hydrochloride) (Item No. 24359) is an analytical reference standard categorized as a local anesthetic. This product is intended for research and forensic applications.
• Uses: Class I antiarrhythmic These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH.
• Clinical Use: Procainamide hydrochloride is metabolized through theaction of N-acetyltransferase. The product of enzymaticmetabolism of procainamide hydrochloride is N-acetylprocainamide(NAPA), which possesses only 25% of the activityof the parent compound.26 A study of the disposition ofprocainamide hydrochloride showed that 50% of the drugwas excreted unchanged in the urine, with 7% to 24% recoveredas NAPA.28,29 Unlike quinidine, procainamide hydrochlorideis bound only minimally to plasma proteins.Between 75% and 95% of the drug is absorbed from the gastrointestinaltract. Plasma levels appear 20 to 30 minutesafter administration and peak in about 1 hour.30Procainamide hydrochloride appears to have all of theelectrophysiological effects of quinidine. It diminishesautomaticity, decreases conduction velocity, and increasesaction potential duration and, thereby, the refractory periodof myocardial tissue. Clinicians have favored the use of procainamidehydrochloride for ventricular tachycardias andquinidine for atrial arrhythmias, even though the two drugsare effective in either type of disorder.

Technology Process of Pronestyl

There total 1 articles about Pronestyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ procainamide hydrochloride (614-39-1)

Guidance literature:

Reference yield: 99.0%

procainamide hydrochloride (614-39-1) + acetic anhydride (108-24-7) → [13C]-Acecainide hydrochloride

Guidance literature:

With pyridine; for 1h;

Reference yield: 98.0%

methyl adipoyl chloride (35444-44-1) + procainamide hydrochloride (614-39-1) → methyl 6-((4-((2-(diethylamino)ethyl)carbamoyl)phenyl)amino)-6-oxohexanoate

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acs.jmedchem.1c00821

Downstream raw materials:

N³-[4-(2-Diethylamino-ethylcarbamoyl)-phenyl]-4-octyloxy-isophthalamide

N³-[4-(2-Diethylamino-ethylcarbamoyl)-phenyl]-4-methoxy-N¹-octyl-isophthalamide

N³-[4-(2-Diethylamino-ethylcarbamoyl)-phenyl]-N¹-isopropyl-4-octyloxy-isophthalamide

N³-[4-(2-Diethylamino-ethylcarbamoyl)-phenyl]-N¹-octyl-4-propoxy-isophthalamide

Refernces