Bikinin

Base Information

• Chemical Name: Bikinin
• CAS No.: 188011-69-0
• Molecular Formula: C₉H₉BrN₂O₃
• Molecular Weight: 273.086
• Hs Code.: 2933399090
• Mol file: 188011-69-0.mol

Synonyms:Butanoic acid, 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-;Bikinin;4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid;4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid;Abrasin;Bikinin(Abrasin)

Chemical Property of Bikinin

Chemical Property:

• Melting Point: 144°C(lit.)
• PSA: 79.29000
• Density: 1.711
• LogP: 1.72040
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ≥5mg/mL

Purity/Quality:

99% ^*data from raw suppliers

Bikinin >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Bikinin has been used: as a glycogen synthase kinase-3 (GSK3) inhibitor in Arabidopsis Col-0 seedlings to test its effect on gene expressionas a component of induction medium and as a GSK3 inhibitor to test its effect on mesophyll cells in Arabidopsis leaf discs or cotyledonsas a brassinosteroid agonist to test its effect on the leaf index of R. trichophyllus terrestrial leaves

Technology Process of Bikinin

There total 2 articles about Bikinin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

succinic acid anhydride (108-30-5) + 5-bromo-2-pyridylamine (1072-97-5) → Bikinin (188011-69-0)

Guidance literature:

In acetone; for 4h; Heating;

DOI:10.1007/BF02223742

Reference yield: 65.0%

→ Bikinin (188011-69-0)

Guidance literature:

Reference yield: 80.0%

4,4,4-trifluorobutanol (461-18-7) + Bikinin (188011-69-0) → 4,4,4-trifluorobutyl 4-[(5-bromo-2-pyridyl)amino]-4-oxo-butanoate (1443415-55-1)

Guidance literature:

With thionyl chloride; at 70 ℃; for 2.08333h;

upstream raw materials:

succinic acid anhydride

5-bromo-2-pyridylamine

Downstream raw materials:

4,4,4-trifluorobutyl 4-[(5-bromo-2-pyridyl)amino]-4-oxo-butanoate

Refernces

• 1、 Burdulene,Stumbryavichyute,Talaikite,Vladyko,Boreko,Korobchenko. "Synthesis and antiviral activity of N-aryl- and N-heterylsuccinamic acids and their salts with 2-amino-2-thiazoline". . p. 680 - 682. Retrieved 2007/10/03.