GNF5

Base Information

• Chemical Name: GNF5
• CAS No.: 778277-15-9
• Molecular Formula: C₂₀H₁₇F₃N₄O₃
• Molecular Weight: 418.375
• Hs Code.: 2933599090
• Mol file: 778277-15-9.mol

Synonyms:GNF 5;GNF5;GNF-5;N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;ert-butyl 2-oxopiperidine-1-carboxylate;GNF 5 N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-5;GNF-5, >=98%

Chemical Property of GNF5

Chemical Property:

• Boiling Point: 612.4±55.0 °C(Predicted)
• PKA: 13.36±0.46(Predicted)
• PSA: 99.86000
• Density: 1.385±0.06 g/cm3(Predicted)
• LogP: 4.15570
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL (clear solution)

Purity/Quality:

98% min ^*data from raw suppliers

GNF 5 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 22-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GNF5

There total 2 articles about GNF5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzoic acid (714962-05-7) + ethanolamine (141-43-5) → GNF-5 (778277-15-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jm100555f

Reference yield:

3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzoic acid (714962-05-7) + 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluranium (HATU) + ethanolamine (141-43-5) + N-ethyl-N,N-diisopropylamine (7087-68-5) → GNF-5 (778277-15-9)

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzoic acid

ethanolamine

N-ethyl-N,N-diisopropylamine

Refernces

• 1、 Deng, Xianming,Okram, Barun,Ding, Qiang,Zhang, Jianming,Choi, Yongmun,Adrián, Francisco J.,Wojciechowski, Amy,Zhang, Guobao,Che, Jianwei,Bursulaya, Badry,Cowan-Jacob, Sandra W.,Rummel, Gabriele,Sim, Taebo,Gray, Nathanael S.. "Expanding the diversity of allosteric Bcr-Abl inhibitors". experimental part. p. 6934 - 6946. Retrieved 2010/12/25.