Tetrahydrofuran-D8

Base Information

• Chemical Name: Tetrahydrofuran-D8
• CAS No.: 1693-74-9
• Molecular Formula: C4D8O
• Molecular Weight: 80.0434
• Hs Code.: 2845 90 10
• European Community (EC) Number: 216-898-4
• DSSTox Substance ID: DTXSID00937620
• Nikkaji Number: J195.342G
• Wikipedia: Deuterated_THF
• Wikidata: Q1101317
• Mol file: 1693-74-9.mol

Synonyms:Tetrahydrofuran-D8;1693-74-9;deuterated thf;Tetrahydrofuran D8;thf-d8;Octadeuterotetrahydrofuran;2,2,3,3,4,4,5,5-octadeuteriooxolane;(2H4)Tetrahydro(2H4)furan;Deuterated tetrahydrofuran;Tetrahydrofuran-d8 99.5atom%D;EINECS 216-898-4;MFCD00044238;[2H4]tetrahydro[2H4]furan;Tetrahydrofuran-d8 (THF-d8);Tetrahydrofuran-d8, >=99.5 atom % D;oxolane-d8;(2H8)Tetrahydrofuran;Furan-d4, tetrahydro-d4-;C4D8O;Furan-D4-, tetrahydro-D4-;C4-D8-O;DTXSID00937620;CHEBI:193047;AKOS015904238;CS-T-61817;Furan-2,3,4,5-d4, tetrahydro-d4-;Tetrahydrofuran-d8, 99.95 atom % D;AS-75562;T2425;T3502;FURAN-2,3,4,5-D4,TETRAHYDRO-D4-;T71908;J-010530;J-524871;Q1101317;Tetrahydrofuran-d8, >=99.5 atom % D, contains 1 % (v/v) TMS;Tetrahydrofuran-d8, >=99.5 atom % D, contains 0.03 % (v/v) TMS

Chemical Property of Tetrahydrofuran-D8

Chemical Property:

• Appearance/Colour: colourless liquid with an ether-like odour
• Vapor Pressure: 152mmHg at 25°C
• Melting Point: -106oC
• Refractive Index: n20/D 1.403(lit.)
• Boiling Point: 68.3 °C at 760 mmHg
• Flash Point: -21oC
• PSA: 9.23000
• Density: 1.005 g/cm³
• LogP: 0.79680
• Storage Temp.: Refrigerator (+4°C)
• Water Solubility.: Soluble in water.
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 80.107728842
• Heavy Atom Count: 5
• Complexity: 22.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tetrahydrofuran-d8 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn,Xi
• Hazard Codes: F,Xn,Xi
• Statements: 11-19-36/37-40
• Safety Statements: 16-29-33-46-37-36-13-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Ethers (
• Canonical SMILES: C1CCOC1
• Isomeric SMILES: [2H]C1(C(C(OC1([2H])[2H])([2H])[2H])([2H])[2H])[2H]
• Uses: Tetrahydrofuran-d_8 is a deuterated THF that is used in various synthesis reactions and also used as a precursor for various polymers.

Technology Process of Tetrahydrofuran-D8

There total 7 articles about Tetrahydrofuran-D8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) → tetrahydrofuran-d8 (1693-74-9)

Guidance literature:

With Cp*(PMe₃)IrCl₂; water-d2; at 135 ℃; for 40h; Product distribution;

DOI:10.1021/ja017219d

Reference yield:

<2H4>dimethyl succinate (30994-23-1) → tetrahydrofuran-d8 (1693-74-9)

Guidance literature:

With lithium aluminium deuteride; diethyl ether; Erhitzen des Reaktionsprodukts mit wasserhaltiger Phosphorsaeure;

DOI:10.1021/jo01091a024

Reference yield:

2C17H29(1-)*3C4(2)H8O*2Li(1+) → tetrahydrofuran-d8 (1693-74-9) + C17H29Li*C4(2)H8O

Guidance literature:

In Cyclopentane; at -5 ℃; Equilibrium constant; Thermodynamic data;

DOI:10.1021/ja00409a005

upstream raw materials:

<2H4>dimethyl succinate

tetrahydrofuran

d⁽⁴⁾-methanol

Downstream raw materials:

ethylbenzene

sec-Butylbenzene

1-Ethylbenzocyclobuten

1-Ethyl-9,10-dihydrophenanthren

Refernces

• 1、 Polukeev, Alexey V.,Marcos, Rocío,Ahlquist, M?rten S. G.,Wendt, Ola F.. "Iridium Hydride Complexes with Cyclohexyl-Based Pincer Ligands: Fluxionality and Deuterium Exchange". . p. 2600 - 2608. Retrieved 2016/09/04.
• 2、 Lee, Joo Ho,Yoo, Kyung Soo,Park, Chan Pil,Olsen, Janet M.,Sakaguchi, Satoshi,Prakash, G. K. Surya,Mathew, Thomas,Jung, Kyung Woon. "An Air/water-stable tridentate N-heterocyclic carbene-palladium(II) Complex: Catalytic C-H activation of hydrocarbons via hydrogen/deuterium exchange process in deuterium oxide". experimental part. p. 563 - 568. Retrieved 2009/11/30.