Technology Process of ent-14,15-Dir-13-oxolabda-8(17),11-dien-18-oic acid
There total 7 articles about ent-14,15-Dir-13-oxolabda-8(17),11-dien-18-oic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dipyridinium dichromate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 7h;
DOI:10.1248/cpb.54.1333
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: KO-tBu / diethyl ether / 0.5 h / 20 °C
1.2: 94 percent / diethyl ether / 7 h / 20 °C
2.1: 61 percent / PPTS / acetone / 3 h / 20 °C
3.1: KO-tBu / tetrahydrofuran / 5 h / -78 °C
4.1: 18.6 mg / aq. H2O2 / CH2Cl2 / 0.33 h / 20 °C
5.1: 97 percent / tetrahydrofuran / 0.25 h / 0 °C
6.1: 100 percent / HMPA; 1-dodecanethiol; n-BuLi / hexane / 2.5 h / 20 °C
7.1: 94 percent / PDC; Celite(R) / dimethylformamide / 7 h / 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dipyridinium dichromate; n-butyllithium; Celite; potassium tert-butylate; dihydrogen peroxide; pyridinium p-toluenesulfonate; 1-dodecylthiol;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
1.2: Wittig reaction;
DOI:10.1248/cpb.50.1625
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / HMPA; 1-dodecanethiol; n-BuLi / hexane / 2.5 h / 20 °C
2: 94 percent / PDC; Celite(R) / dimethylformamide / 7 h / 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dipyridinium dichromate; n-butyllithium; Celite; 1-dodecylthiol;
In
hexane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.50.1625
