4-BROMO-1-TERT-BUTYL-2-METHOXYBENZENE

Base Information

• Chemical Name: 4-BROMO-1-TERT-BUTYL-2-METHOXYBENZENE
• CAS No.: 30788-02-4
• Molecular Formula: C11H15BrO
• Molecular Weight: 243.14
• Mol file: 30788-02-4.mol

Synonyms:4-BROMO-1-TERT-BUTYL-2-METHOXYBENZENE

Chemical Property of 4-BROMO-1-TERT-BUTYL-2-METHOXYBENZENE

Chemical Property:

• PSA: 9.23000
• LogP: 3.75520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-1-TERT-BUTYL-2-METHOXYBENZENE

There total 2 articles about 4-BROMO-1-TERT-BUTYL-2-METHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-methoxyphenyl bromide (2398-37-0) + tertiary butyl chloride (507-20-0) → 5-Bromo-2-(1,1-dimethylethyl)-1-methoxybenzene (30788-02-4)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1021/acs.joc.1c00880

Reference yield:

→ 5-Bromo-2-(1,1-dimethylethyl)-1-methoxybenzene (30788-02-4)

Guidance literature:

3-Bromanisol, t-Butylchlorid, Gegenwart v. AlCl3;

DOI:10.1021/jo00818a005

Reference yield: 90.0%

5-Bromo-2-(1,1-dimethylethyl)-1-methoxybenzene (30788-02-4) → 5-bromo-2-tert-butyl-phenol (30715-50-5)

Guidance literature:

With boron tribromide; In dichloromethane; 1.) -78 deg C, 30 min, 2.) 25 deg C, 12 h;

DOI:10.1021/jo00104a040

upstream raw materials:

3-methoxyphenyl bromide

tertiary butyl chloride

Downstream raw materials:

3-bromo-6-tert-butyl-2,4-dinitro-anisole

5-bromo-2-tert-butyl-phenol

2,2'-Methylenebis<3-bromo-6-(1,1-dimethylethyl)phenol>

1-tert-butyl-2,4-dimethoxy-3,5-dinitro-benzene

Refernces

• 1、 Ise, Tomoaki,Morita, Yasushi,Murata, Tsuyoshi,Sato, Kazunobu,Shiomi, Daisuke,Takui, Takeji,Ueda, Akira,Yamamoto, Yosuke. "Synthesis and Physical Properties of Trioxotriangulene Having Methoxy and Hydroxy Groups at α-Positions: Electronic and Steric Effects of Substituent Groups and Intramolecular Hydrogen Bonds". . p. 10154 - 10165. Retrieved 2021.