Vonoprazan FuMarate

Base Information

• Chemical Name: Vonoprazan FuMarate
• CAS No.: 881681-01-2
• Molecular Formula: C₄H₄O₄*C₁₇H₁₆FN₃O₂S
• Molecular Weight: 461.471
• Mol file: 881681-01-2.mol

Synonyms:5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate

Chemical Property of Vonoprazan FuMarate

Chemical Property:

• PSA: 146.97000
• LogP: 3.82910

Purity/Quality:

VonoprazanFumarate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Vonoprazan FuMarate

There total 56 articles about Vonoprazan FuMarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

5-(2-fluorophenyl)-3-bromomethyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole + methylamine (74-89-5) + 2-butenedioic acid (6915-18-0,26099-09-2) → 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (2098974-13-9,881681-01-2)

Guidance literature:

5-(2-fluorophenyl)-3-bromomethyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole; methylamine; With triethylamine; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; In toluene; at 25 ℃; for 4h;

2-butenedioic acid; In N,N-dimethyl-formamide; at 40 ℃; for 2h; Reagent/catalyst;

Reference yield: 90.2%

5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile (1807642-39-2) + methylamine hydrochloride (593-51-1) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt (2098974-13-9,881681-01-2)

Guidance literature:

5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile; methylamine hydrochloride; With phosgene; sodium tetrahydroborate; bis[2-(di-tert-butylphosphino)ethyl]amine; sodium hydroxide; In tetrahydrofuran; for 10h; Inert atmosphere; Reflux;

(2E)-but-2-enedioic acid; at 20 ℃; for 1h; Solvent; Reagent/catalyst;

Reference yield: 90.0%

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine (881681-00-1) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt (2098974-13-9,881681-01-2)

Guidance literature:

In methanol; at 25 - 50 ℃; for 0.5h; Temperature;

upstream raw materials:

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine

(2E)-but-2-enedioic acid

5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde

methylamine methanol

Refernces

• 1、 -. "Vonoprazan fumarate intermediate and preparation method thereof". Paragraph 0039; 0084; 0086-0087; 0089-0090; 0092. . Retrieved 2021/10/27.
• 2、 -. "Preparation method of tenosynol fumarate". Paragraph 0045-0051. . Retrieved 2021/11/19.