GLPG0634

Base Information

• Chemical Name: GLPG0634
• CAS No.: 1206101-20-3
• Molecular Formula: C23H18N6O2
• Molecular Weight: 410.435
• Mol file: 1206101-20-3.mol

Synonyms:CS-1887;GLPG634 analog;Filgotinib analog;GLPG0634 analogue;GLPG0634 analog, Filgotinib analog;N-[5-[4-[(6-cyano-3-pyridinyl)Methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxaMide;N-(5-(4-((6-cyanopyridin-3-yl)methoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide;Cyclopropanecarboxamide, N-[5-[4-[(6-cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-;N-[5-[4-[(6-Cyano-3-pyridinyl)Methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxaMide (GLPG0634);N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide GLPG0634 analogue

Chemical Property of GLPG0634

Chemical Property:

• PSA: 108.43000
• LogP: 3.01238
• Solubility.: insoluble in EtOH; insoluble in H2O; ≥31.67 mg/mL in DMSO with gentle warming

Purity/Quality:

98%,99%, ^*data from raw suppliers

GLPG0634analogue ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, is an orally-available, selective inhibitor of JAK1 (Janus kinase 1), used for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.

Technology Process of GLPG0634

There total 1 articles about GLPG0634 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide (1142943-96-1) + 5-[4-(4, 4, 5, 5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-pyridine-2-carbonitrile (1206101-28-1) → GLPG0634 (1206101-20-3)

Guidance literature:

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

Reference yield:

GLPG0634 (1206101-20-3) → 5-{4-[2-(Cyclopropanecarbonyl-amino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-phenoxymethyl}-pyridine-2-carboxylic acid amide (1206161-89-8)

Guidance literature:

With dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; at 10 - 20 ℃;

upstream raw materials:

cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

5-[4-(4, 4, 5, 5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-pyridine-2-carbonitrile

Downstream raw materials:

5-{4-[2-(Cyclopropanecarbonyl-amino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-phenoxymethyl}-pyridine-2-carboxylic acid amide

Refernces