Vortioxetine hydrobromide

Base Information

• Chemical Name: Vortioxetine hydrobromide
• CAS No.: 960203-27-4
• Molecular Formula: C18H23BrN2S
• Molecular Weight: 379.364
• Hs Code.: 29339900
• Mol file: 960203-27-4.mol

Synonyms:Lu AA 21004 hydrobromide; Vortioxetine hydrobromide

Chemical Property of Vortioxetine hydrobromide

Chemical Property:

• PSA: 40.57000
• LogP: 5.21610
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC>99% ^*data from raw suppliers

VortioxetineHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Vortioxetine Hydrobromide is a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).

Technology Process of Vortioxetine hydrobromide

There total 96 articles about Vortioxetine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

vortioxetine (508233-74-7) → Vortioxetine hydrobromide (960203-27-4)

Guidance literature:

With hydrogen bromide; In water; isopropyl alcohol; for 0.166667h; Concentration; Solvent; Sonication;

Reference yield: 90.2%

piperazine (110-85-0) + (2′-bromophenyl)(2,4-dimethylphenyl)sulfane (960203-41-2) → Vortioxetine hydrobromide (960203-27-4)

Guidance literature:

piperazine; (2′-bromophenyl)(2,4-dimethylphenyl)sulfane; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 105 - 115 ℃; Inert atmosphere;

With hydrogen bromide; at 20 - 40 ℃; Concentration;

Reference yield: 89.6%

bis(2-bromoethyl)amine hydrobromide (43204-63-3) + 2-(2,4-dimethylphenylsulphanyl)benzeneamine (1019453-85-0) → Vortioxetine hydrobromide (960203-27-4)

Guidance literature:

at 100 - 180 ℃; for 9h; Temperature;

upstream raw materials:

1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine hydrobromide ethyl acetate solvate

(2S,3S,4S,5R,6S)-6-{4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-1-β-D-glucuronic acid-piperazine-1-oxide

2-(2,4-dimethylphenylsulphanyl)benzeneamine

Downstream raw materials:

vortioxetine

4-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "Preparation method of novel severe depression treatment drug". Paragraph 0033; 0035; 0037-0040; 0042; 0044; 0050; 0052; .... . Retrieved 2021/10/16.
• 2、 -. "Manufacturing method of vortioxetine hydrobromide". Paragraph 0056; 0073-0077. . Retrieved 2021/11/30.