MI-3 (Menin-MLL Inhibitor)

Base Information

• Chemical Name: MI-3 (Menin-MLL Inhibitor)
• CAS No.: 1271738-59-0
• Molecular Formula: C18H25N5S2
• Molecular Weight: 375.5546
• Mol file: 1271738-59-0.mol

Synonyms:MI-3;Menin-MLL inhibitor 3;Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine

Chemical Property of MI-3 (Menin-MLL Inhibitor)

Chemical Property:

• Boiling Point: 527.9±60.0 °C(Predicted)
• PKA: 9.59±0.40(Predicted)
• PSA: 98.16000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 3.25660

Purity/Quality:

98%min ^*data from raw suppliers

MI-3(Menin-MLLInhibitor) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.
• Uses: MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.