CZC24832

Base Information

• Chemical Name: CZC24832
• CAS No.: 1159824-67-5
• Molecular Formula: C15H17FN6O2S
• Molecular Weight: 364.4
• Mol file: 1159824-67-5.mol

Synonyms:CZC24832;5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide

Chemical Property of CZC24832

Chemical Property:

• PKA: 10.29±0.50(Predicted)
• PSA: 124.38000
• Density: 1.51
• LogP: 2.99120
• Solubility.: insoluble in H2O; insoluble in EtOH; ≥6.07 mg/mL in DMSO with gentle warming

Purity/Quality:

99%+, ^*data from raw suppliers

CZC 24832 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CZC24832 is a selective phosphoinositide 3-kinase γ (PI3Kγ) inhibitor. CZC24832 regulates interleukin-17-producing T helper cell (TH17) differentiation by PI3Kγ thus making CZC24832 a potential treatment for inflammatory and autoimmune diseases.

Technology Process of CZC24832

There total 2 articles about CZC24832 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H19FN6O3S → CZC24832 (1159824-67-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2012.06.049

Reference yield:

→ CZC24832 (1159824-67-5)

Guidance literature:

Refernces

• 1、 -. "UREA TRIAZOLOLO [1, 5-A] PYRIDINE DERIVATIVES AS PI3K INHIBITORS". Page/Page column 50. . Retrieved 2010/09/03.