Wnt-C59

Base Information

• Chemical Name: Wnt-C59
• CAS No.: 1243243-89-1
• Molecular Formula: C25H21N3O
• Molecular Weight: 379.461
• Hs Code.: 2933399090
• Mol file: 1243243-89-1.mol

Synonyms:S7037,C59;QC-8389;CS-1420;Wnt-C59;2-[4-(2-methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide;Wnt-C59 (C59);

Chemical Property of Wnt-C59

Chemical Property:

• Boiling Point: 628.3±55.0 °C(Predicted)
• PKA: 13.78±0.70(Predicted)
• PSA: 54.88000
• Density: 1.198±0.06 g/cm3(Predicted)
• LogP: 5.37320
• Storage Temp.: +2C to +8C
• Solubility.: Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)

Purity/Quality:

99% ^*data from raw suppliers

Wnt-C59 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4
• Uses: Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.