7-(2,5-Dihydroxy-3,4,6-triMethylphenyl)-7-phenylheptanoic acid

Base Information

• Chemical Name: 7-(2,5-Dihydroxy-3,4,6-triMethylphenyl)-7-phenylheptanoic acid
• CAS No.: 148989-73-5
• Molecular Formula: C22H28O4
• Molecular Weight: 356.462
• Mol file: 148989-73-5.mol

Synonyms:7-(2,5-Dihydroxy-3,4,6-triMethylphenyl)-7-phenylheptanoic acid

Chemical Property of 7-(2,5-Dihydroxy-3,4,6-triMethylphenyl)-7-phenylheptanoic acid

Chemical Property:

• Boiling Point: 586.5±50.0 °C(Predicted)
• PKA: 4.77±0.10(Predicted)
• Density: 1.153±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-(2,5-Dihydroxy-3,4,6-trimethylphenyl)-7-phenylheptanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-(2,5-Dihydroxy-3,4,6-triMethylphenyl)-7-phenylheptanoic acid

There total 5 articles about 7-(2,5-Dihydroxy-3,4,6-triMethylphenyl)-7-phenylheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethylhydroquinone (700-13-0) + 7-hydroxy-7-phenylheptanoic acid (103187-18-4,122114-99-2) → 7-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-7-phenyl-heptanoic acid (148989-73-5)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; at 60 ℃; for 2h;

DOI:10.1021/jm00129a030

Reference yield:

ethyl 6-(chloroformyl)hexanoate (14794-32-2) → 7-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-7-phenyl-heptanoic acid (148989-73-5)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃ / 2 h / 90 °C

2: NaBH₄ / methanol / 0.5 h / 0 °C

3: 95 percent / 2.5 N NaOH / tetrahydrofuran / 3 h / 70 °C

4: boron trifluoride etherate / toluene / 2 h / 60 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/jm00129a030

Reference yield:

7-ethoxy-7-oxoheptanoic acid (33018-91-6) → 7-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-7-phenyl-heptanoic acid (148989-73-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / SOCl₂ / CH₂Cl₂ / 2 h / 50 °C

2: AlCl₃ / 2 h / 90 °C

3: NaBH₄ / methanol / 0.5 h / 0 °C

4: 95 percent / 2.5 N NaOH / tetrahydrofuran / 3 h / 70 °C

5: boron trifluoride etherate / toluene / 2 h / 60 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1021/jm00129a030

upstream raw materials:

Trimethylhydroquinone

7-hydroxy-7-phenylheptanoic acid

ethyl 6-(chloroformyl)hexanoate

7-ethoxy-7-oxoheptanoic acid

Downstream raw materials:

p-nitrophenyl 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoate

(-)-AA 2414

(+)-AA 2414

seratrodast

Refernces

• 1、 Shiraishi,Kato,Terao,Ashida,Terashita,Kito. "Quinones. 4. Novel eicosanoid antagonists: Synthesis and pharmacological evaluation". . p. 2214 - 2221. Retrieved 2007/10/02.