Multi-step reaction with 6 steps
1.1: tin(ll) chloride / ethanol / 2 h / 90 °C
1.2: 6 h / Reflux
1.3: 24 h / 90 °C
2.1: N-Bromosuccinimide / acetonitrile / 2 h / 20 - 30 °C
3.1: bis(tri-t-butylphosphine)palladium(0); N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Sealed tube
4.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 3 h / 50 °C
4.2: 0 °C / pH 2
5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 - 30 °C
6.1: sodium hydroxide / tetrahydrofuran; methanol; N,N-dimethyl-formamide / 0.5 h / 20 - 30 °C
With
N-Bromosuccinimide; bis(tri-t-butylphosphine)palladium(0); lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;