Dovitinib Dilactic acid (TKI258 Dilactic acid)

Base Information

• Chemical Name: Dovitinib Dilactic acid (TKI258 Dilactic acid)
• CAS No.: 852433-84-2
• Molecular Formula: 2C₃H₆O₃*C₂₁H₂₁FN₆O
• Molecular Weight: 572.593
• Mol file: 852433-84-2.mol

Synonyms:TKI258 Dilactic acid;2-Hydroxypropanoic acid compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone;

Chemical Property of Dovitinib Dilactic acid (TKI258 Dilactic acid)

Chemical Property:

• PSA: 209.36000
• LogP: 2.44450

Purity/Quality:

98%,99%, ^*data from raw suppliers

DovitinibDilacticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dovitinib Dilactic acid is the Dilactic acid of Dovitinib (D537000, Lactate salt), which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit), also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Potent FGFR inhibitor

Technology Process of Dovitinib Dilactic acid (TKI258 Dilactic acid)

There total 7 articles about Dovitinib Dilactic acid (TKI258 Dilactic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one (405169-16-6,804551-71-1) + LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) → 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt (692737-80-7,852433-84-2)

Guidance literature:

In ethanol; water; at 68 - 72 ℃; for 0.25 - 0.75h;

Reference yield:

1-methyl-piperazine (109-01-3) → 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt (692737-80-7,852433-84-2)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 20 - 100 °C

2: hydrogen / 5%-palladium/activated carbon / ethanol; water / 40 - 55 °C

3: 0.25 h / 40 - 55 °C

4: potassium hexamethylsilazane / tetrahydrofuran / 0.67 - 1.08 h / 38 - 63 °C

5: ethanol; water / 0.25 - 0.75 h / 68 - 72 °C

With hydrogen; potassium hexamethylsilazane; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; water;

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one DL-lactic acid salt (692737-80-7,852433-84-2)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 20 - 100 °C

2: hydrogen / 5%-palladium/activated carbon / ethanol; water / 40 - 55 °C

3: 0.25 h / 40 - 55 °C

4: potassium hexamethylsilazane / tetrahydrofuran / 0.67 - 1.08 h / 38 - 63 °C

5: ethanol; water / 0.25 - 0.75 h / 68 - 72 °C

With hydrogen; potassium hexamethylsilazane; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; water;

upstream raw materials:

4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one

LACTIC ACID

1-methyl-piperazine

[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]acetic acid ethyl ester

Refernces

• 1、 -. "CRYSTALLINE FORMS AND TWO SOLVATED FORMS OF 4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE LACTIC ACID SALTS". Page/Page column 8. . Retrieved 2009/10/22.
• 2、 -. "Formulation of Quinolinones". Page/Page column 16. . Retrieved 2009/01/20.