Imatinib related substance B

Base Information

• Chemical Name: Imatinib related substance B
• CAS No.: 571186-93-1
• Molecular Formula: C₂₉H₃₁N₇O₃
• Molecular Weight: 525.61
• Mol file: 571186-93-1.mol

Synonyms:1,4-dioxide iMatinib;iMatinib related substance B;4-[(4-Methyl-1,4-dioxido-1-piperazinyl)Methyl]-N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]phenyl]benzaMide;IMatinib (Piperidine)-N,N-dioxide;4-[4-Methyl- 1.4-dioxidepiperazin-1-yl] Methyl-N-[4 -Methyl-3-[[ 4-(pyridin-3-yl)pyriMidin-2- yl]aMino]phenyl]benzaMide

Chemical Property of Imatinib related substance B

Chemical Property:

• PKA: 12.76±0.70(Predicted)
• PSA: 138.66000
• LogP: 4.67910
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imatinib(Piperidine)-N,N-dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Imatinib (Piperidine)-N,N-dioxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity B. Imatinib (Piperidine)-N,N-dioxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity B. It is a COVID19-related research product.

Technology Process of Imatinib related substance B

There total 1 articles about Imatinib related substance B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

imatinib (152459-95-5) → 1-methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine-1,4-dioxide (571186-93-1)

Guidance literature:

With dihydrogen peroxide; at 25 ℃; for 12h;

DOI:10.1007/s11164-012-0987-x

upstream raw materials:

imatinib

Refernces

• 1、 Manley, Paul W.. "Investigations into the potential role of metabolites on the anti-leukemic activity of imatinib, nilotinib and midostaurin". . p. 561 - 570. Retrieved 2019/09/03.