2,6-difluoro-3-nitroaniline

Base Information

• Chemical Name: 2,6-difluoro-3-nitroaniline
• CAS No.: 25892-09-5
• Molecular Formula: C6H4F2N2O2
• Molecular Weight: 174.107
• Hs Code.: 2921420090
• Mol file: 25892-09-5.mol

Synonyms:2,6-Difluoro-3-nitrobenzenamine; Benzenamine, 2,6-difluoro-3-nitro-; ZR BF FF CNW

Chemical Property of 2,6-difluoro-3-nitroaniline

Chemical Property:

• Vapor Pressure: 0.0028mmHg at 25°C
• Boiling Point: 285.5°C at 760 mmHg
• PKA: -0.26±0.10(Predicted)
• Flash Point: 126.4°C
• PSA: 71.84000
• Density: 1.554g/cm³
• LogP: 2.55960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Difluoro-3-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-difluoro-3-nitroaniline

There total 3 articles about 2,6-difluoro-3-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azido-1,3-difluoro-4-nitrobenzene → 2,6-difluoro-3-nitroaniline (25892-09-5)

Guidance literature:

2-azido-1,3-difluoro-4-nitrobenzene; With trimethylphosphane; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

With water; In tetrahydrofuran; toluene; at 50 ℃; for 12h;

DOI:10.1021/jacs.7b07661

Reference yield:

2,4-Difluoronitrobenzene (446-35-5) → 2,6-difluoro-3-nitroaniline (25892-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidylzinc chloride lithium chloride / tetrahydrofuran; hexane / 1 h / 20 °C

1.2: 3 h / 0 - 20 °C

2.1: trimethylphosphane / tetrahydrofuran; toluene / 1 h / 20 °C

2.2: 12 h / 50 °C

With 2,2,6,6-tetramethylpiperidylzinc chloride lithium chloride; trimethylphosphane; In tetrahydrofuran; hexane; toluene; 2.1: |Staudinger Azide Reduction / 2.2: |Staudinger Azide Reduction;

DOI:10.1021/jacs.7b07661

Reference yield:

→ 2,6-difluoro-3-nitroaniline (25892-09-5)

Guidance literature:

aus 2,6-Difluor-3-nitroacetanilid <1> mit konz. HCl in A. ;

upstream raw materials:

2,4-Difluoronitrobenzene

Downstream raw materials:

tert-butyl (2,6-difluoro-3-nitrophenyl)carbamate

tert-butyl (3-amino-2,6-difluorophenyl)carbamate

Refernces