L-A-GLYCERYLPHOSPHORYLCHOLINE(GPC)

Base Information

• Chemical Name: L-A-GLYCERYLPHOSPHORYLCHOLINE(GPC)
• CAS No.: 4217-84-9
• Molecular Formula: C8H20NO6P
• Molecular Weight: 257.224
• Mol file: 4217-84-9.mol

Synonyms:L-A-GLYCERYLPHOSPHORYLCHOLINE(GPC);2-[[(S)-2,3-Dihydroxypropyl]oxy(oxylato)phosphinyloxy]-N,N,N-trimethylethanaminium;D-Glycero-3-phosphocholine;D-Glycerol 3-phosphorylcholine;D-Glycerolphosphocholine;D-Glycerophosphocholine;D-Glycerophosphorylcholin

Chemical Property of L-A-GLYCERYLPHOSPHORYLCHOLINE(GPC)

Chemical Property:

• PSA: 108.86000
• LogP: -0.38240
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

(S)-α-Glycerophosphocholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: α-Glycerylphosphorylcholine is a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer''s disease and other dementias.

Technology Process of L-A-GLYCERYLPHOSPHORYLCHOLINE(GPC)

There total 7 articles about L-A-GLYCERYLPHOSPHORYLCHOLINE(GPC) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

L-α-glycerophosphorylcholine chloride (960075-50-7) → (S)-2,3-dihydroxypropyl (2-(trimethylammonio)ethyl)phosphate (4217-84-9,563-24-6)

Guidance literature:

With IONAC NM₆₀ SG ion exchange resin; In water;

Reference yield: 90.0%

1,2-Diheptanoyl-3-L-α-phosphatidylcholine (3436-45-1) → (S)-2,3-dihydroxypropyl (2-(trimethylammonio)ethyl)phosphate (4217-84-9,563-24-6)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Reflux; Inert atmosphere; Darkness;

DOI:10.1039/c6cc09305a

Reference yield:

diplasmenylcholine → n-hexadecylaldehyde (629-80-1) + (S)-2,3-dihydroxypropyl (2-(trimethylammonio)ethyl)phosphate (4217-84-9,563-24-6)

Guidance literature:

With water; at 37 ℃; for 48h; Rate constant; Product distribution; var. pH value;

DOI:10.1021/ja9742949

upstream raw materials:

trimethylamine

L-α-glycerophosphorylcholine chloride

C₁₃H₂₆N₄O₅P⁽¹⁺⁾

1,2-Diheptanoyl-3-L-α-phosphatidylcholine

Refernces

• 1、 -. "Glycerin phosphatidyl choline preparation method". Paragraph 0030; 0063; 0064; 0065; 0066. . Retrieved 2018/04/20.
• 2、 -. "A L-α-Ganong choline phosphate preparation method". Paragraph 0051-0053. . Retrieved 2017/03/18.