Bergenin pentaacetate

Base Information

• Chemical Name: Bergenin pentaacetate
• CAS No.: 14531-47-6
• Molecular Formula: C24H26O14
• Molecular Weight: 538.45
• Mol file: 14531-47-6.mol

Synonyms:Bergenin pentaacetate;Bergenin 3,4,8,10,11-pentaacetate

Chemical Property of Bergenin pentaacetate

Chemical Property:

• PSA: 176.26000
• LogP: 0.95120

Purity/Quality:

98%Min ^*data from raw suppliers

Bergeninpentaacetate ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bergenin pentaacetate

There total 7 articles about Bergenin pentaacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

acetic anhydride (108-24-7) + bergenin (477-90-7) → 3,4,8,10,11-penta-O-acetylbergenin (14531-47-6)

Guidance literature:

With pyridine;

DOI:10.1016/0008-6215(91)80113-2

Reference yield: 71.0%

bergenin (477-90-7) + acetyl chloride (75-36-5) → 3,4,8,10,11-penta-O-acetylbergenin (14531-47-6)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 16h;

DOI:10.1111/j.1747-0285.2011.01194.x

Reference yield:

bergenin (477-90-7) + acetyl chloride (75-36-5) → (8-acetoxy-3,4,10-trihydroxy-9-methoxy-6-oxo-2,3,4,4a,6,10b-hexahydropyrano[3,2-c]isochromen-2-yl)methyl acetate + 2-(acetoxymethyl)-4-hydroxy-9-methoxy-6-oxo-2,3,4,4a,6,10b-hexahydropyrano[3,2-c]isochromene-3,8,10-triyl triacetate + 3,4,8,10,11-penta-O-acetylbergenin (14531-47-6)

Guidance literature:

bergenin; With pyridine; at 0 - 5 ℃; for 0.166667h;

acetyl chloride; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2017.08.011

upstream raw materials:

acetic anhydride

bergenin

acetyl chloride

Refernces

• 1、 Singh, Rohit,Kumar, Vikas,Bharate, Sonali S.,Vishwakarma, Ram A.. "Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis". . p. 5513 - 5521. Retrieved 2017/10/06.
• 2、 Murthy, Y. L. N.,Jairaj, M. A.. "Crystalline Constituents of Flueggea microcarpa Blume". . p. 738 - 739. Retrieved 2007/10/02.