4-Fluoropicolinamide

Base Information

• Chemical Name: 4-Fluoropicolinamide
• CAS No.: 1172938-55-4
• Molecular Formula: C6H5FN2O
• Molecular Weight: 140
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60592835
• Wikidata: Q72476775
• Mol file: 1172938-55-4.mol

Synonyms:4-Fluoropicolinamide;1172938-55-4;4-Fluoropyridine-2-carboxamide;2-Pyridinecarboxamide, 4-fluoro-;MFCD12026314;SCHEMBL7692385;DTXSID60592835;AKOS006317977;AKOS015950529;SB53572;4-Fluoropyridine-2-carboxylic acid amide;AS-31504;SY007027;DB-060992;CS-0207680;A893406;J-515425;W-204935

Chemical Property of 4-Fluoropicolinamide

Chemical Property:

• Boiling Point: 275℃
• PKA: 14.53±0.50(Predicted)
• Flash Point: 120℃
• PSA: 55.98000
• Density: 1.327
• LogP: 1.01990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 140.03859095
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluoropicolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1F)C(=O)N

Technology Process of 4-Fluoropicolinamide

There total 4 articles about 4-Fluoropicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-fluoropyridine-2-carboxylic acid (886371-78-4) → 4-fluoropyridine-2-carboxamide (1172938-55-4)

Guidance literature:

4-fluoropyridine-2-carboxylic acid; With pyridine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.5h;

With ammonium formate; In tetrahydrofuran; for 0.5h; Reagent/catalyst;

Reference yield: 87.6%

4-fluoro-2-pyridinecarbonitrile → 4-fluoropyridine-2-carboxamide (1172938-55-4)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In ethanol; at 20 ℃; Temperature; Solvent;

Reference yield:

4-chloro-pyridine-2-carbonitrile (19235-89-3) → 4-fluoropyridine-2-carboxamide (1172938-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium fluoride / N,N-dimethyl-formamide / 120 - 140 °C / Inert atmosphere

2: sodium hydroxide; dihydrogen peroxide / ethanol / 20 °C

With potassium fluoride; tetrabutylammomium bromide; dihydrogen peroxide; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

4-chloro-pyridine-2-carbonitrile

2-Picolinic acid

4-fluoropyridine-2-carboxylic acid

Refernces

• 1、 -. "Synthesis method of 2-amino-4-fluoropyridine". . . Retrieved 2021/03/30.