XL888

Base Information

• Chemical Name: XL888
• CAS No.: 1149705-71-4
• Molecular Formula: C29H37N5O3
• Molecular Weight: 503.64
• Mol file: 1149705-71-4.mol

Synonyms:XL888;5-((R)-sec-butylaMino)-N1-((1R,3r,5S)-8-(5-(cyclopropanecarbonyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-2-MethylterephthalaMide

Chemical Property of XL888

Chemical Property:

• Boiling Point: 695.1±55.0 °C(Predicted)
• PKA: 14.33±0.20(Predicted)
• PSA: 121.90000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 5.81880
• Solubility.: insoluble in H2O; insoluble in EtOH; ≥18.2 mg/mL in DMSO

Purity/Quality:

99% ^*data from raw suppliers

XL888 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: XL888, is a heat shock protein 90 (Hsp90) inhibitor. HSP90, is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.1 XL888 is an ATP-competitive inhibitor of Hsp90.2 Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis.3,4,5 XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice