4,6-dichloronicotinaldehyde

Base Information

• Chemical Name: 4,6-dichloronicotinaldehyde
• CAS No.: 1060811-62-2
• Molecular Formula: C6H3Cl2NO
• Molecular Weight: 176.002
• Hs Code.: 2933399090
• Mol file: 1060811-62-2.mol

Synonyms:4,6-Dichloropyridine-3-carbaldehyde

Chemical Property of 4,6-dichloronicotinaldehyde

Chemical Property:

• Boiling Point: 268.2±35.0 °C(Predicted)
• PKA: -1.17±0.10(Predicted)
• PSA: 29.96000
• Density: 1.488±0.06 g/cm3(Predicted)
• LogP: 2.20090
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

4,6-Dichloronicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-dichloronicotinaldehyde

There total 10 articles about 4,6-dichloronicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-dichloro-5-hydroxymethylpyridine (73998-95-5) → 2,4-dichloro-5-pyridinecarboxaldehyde (1060811-62-2)

Guidance literature:

With manganese(IV) oxide; In chloroform; at 75 ℃; for 12h;

Reference yield: 87.52%

ethyl 4,6-dichloronicotinate (40296-46-6) → 2,4-dichloro-5-pyridinecarboxaldehyde (1060811-62-2)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;

Reference yield: 75.0%

C9H11Cl2NOSi → 2,4-dichloro-5-pyridinecarboxaldehyde (1060811-62-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In water; at 5 ℃; for 0.0833333h;

upstream raw materials:

methyl 4,6-dichloropyridine-3-carboxylate

2,4-dichloro-5-hydroxymethylpyridine

ethyl 4,6-dichloronicotinate

3-oxopentanedioic acid dimethyl ester

Downstream raw materials:

6-chloro-1H-pyrazolo[4,3-c]pyridine

3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-methoxyethyl)-1,6-naphthyridin-2(1H)-one

1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

Refernces

• 1、 Sree Lakshmana Rao,Basaveswara Rao, Mandava V.,Prasad. "Synthesis and antibacterial evaluation of hydrazone derivatives bearing 6-chlorothieno[3,2-c]pyridine Moiety". . p. 627 - 632. Retrieved 2019.
• 2、 -. "3,4-dihydropyrido[4,3-d]pyrimidine derivative, and preparation method and use thereof". Paragraph 0069; 0072; 0086-0088. . Retrieved 2019/10/07.