9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Base Information

• Chemical Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
• CAS No.: 1124329-14-1
• Molecular Formula: C24H32N6O3
• Molecular Weight: 453
• Mol file: 1124329-14-1.mol

Synonyms:AZ 3146;

Chemical Property of 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Chemical Property:

• Boiling Point: 621.0±65.0 °C(Predicted)
• PKA: 8.29±0.10(Predicted)
• PSA: 86.44000
• Density: 1.279
• LogP: 3.48120
• Storage Temp.: Store at +4°C
• Solubility.: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)

Purity/Quality:

98% min ^*data from raw suppliers

AZ3146 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2
• Uses: AZ 3146 is a protein kinase Mps1 inhibitor.

Technology Process of 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

There total 1 articles about 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ az3146 (1124329-14-1)

Guidance literature:

Refernces