4,5,7-Trichloro Quinoline

Base Information

• Chemical Name: 4,5,7-Trichloro Quinoline
• CAS No.: 23834-01-7
• Molecular Formula: C9H4Cl3N
• Molecular Weight: 232.496
• Hs Code.: 2933499090
• Mol file: 23834-01-7.mol

Synonyms:Trichloro Quinoline

Chemical Property of 4,5,7-Trichloro Quinoline

Chemical Property:

• Appearance/Colour: Type white crystalline powders
• Vapor Pressure: 0.000405mmHg at 25°C
• Refractive Index: 1.667
• Boiling Point: 327oC
• Flash Point: 181.2oC
• PSA: 12.89000
• Density: 1.523g/cm3
• LogP: 4.19500
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Sparingly), Toluene (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

4,5,7-Trichloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5,7-Trichloroquinoline is an intermediate in synthesizing Quinoxyfen-d4 (Q765502), an isotope labelled Quinoxyfen acts as an agricultural fungicide.

Technology Process of 4,5,7-Trichloro Quinoline

There total 9 articles about 4,5,7-Trichloro Quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

4-hydroxy-5,7-dichloroquinoline (171850-29-6,21873-52-9) → 4,5,7-trichloroquinoline (23834-01-7)

Guidance literature:

With trichlorophosphate; at 140 ℃; for 1h;

DOI:10.1021/ja010654n

Reference yield: 75.0%

5,7-dichloro-1,2,3,4-tetrahydroquinolin-4-one → 4,5,7-trichloroquinoline (23834-01-7)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 120 ℃; for 13h; Solvent; Temperature; Reagent/catalyst;

Reference yield:

3,5-dichlorohydroxyquinoline → 4,5,7-trichloroquinoline (23834-01-7)

Guidance literature:

With thionyl chloride; In sulfolane; N,N-dimethyl-formamide;

upstream raw materials:

4-hydroxy-5,7-dichloroquinoline

3,5-Dichloroaniline

5,7-dichlorokynurenic acid

5,7-dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

Downstream raw materials:

N⁴,N⁴-diethyl-N¹-(5,7-dichloro-[4]quinolyl)-1-methyl-butanediyldiamine

5,7-dichloro-4-(4-fluorophenoxy)quinoline

Refernces

• 1、 -. "A phenoxy quinoline and its synthetic method (by machine translation)". Paragraph 0061-0062; 0071-0072; 0077-0078; 0083; 0085-0086. . Retrieved 2018/11/04.
• 2、 Chandrasekhar,Prasad,Eswaraiah,Venkateswaralu. "Development of an efficient process for 4,5,7-trichloroquinoline, a key intermediate for agrochemical synthesis". . p. 242 - 245. Retrieved 2013/09/06.