5-Bromo-6-methyl-2-pyridinecarbonitrile

Base Information

• Chemical Name: 5-Bromo-6-methyl-2-pyridinecarbonitrile
• CAS No.: 1173897-86-3
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933399090
• Mol file: 1173897-86-3.mol

Synonyms:5-bromo-6-methylpyridine-2-carbonitrile

Chemical Property of 5-Bromo-6-methyl-2-pyridinecarbonitrile

Chemical Property:

• Boiling Point: 273 oC
• PKA: -1.95±0.10(Predicted)
• Flash Point: 119 oC
• PSA: 36.68000
• Density: 1.61
• LogP: 2.02418
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

5-Bromo-6-methylpicolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-6-methyl-2-pyridinecarbonitrile

There total 10 articles about 5-Bromo-6-methyl-2-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-bromo-6-iodo-2-methylpyridine (1008361-77-0) + copper(l) cyanide → 5-bromo-6-methylpyridine-2-carbonitrile (1173897-86-3)

Guidance literature:

With sodium cyanide; In acetonitrile; at 80 ℃; for 16.5h; Inert atmosphere;

Reference yield: 79.0%

sodium cyanide (773837-37-9) + 3-bromo-6-iodo-2-methylpyridine (1008361-77-0) + copper(l) cyanide → 5-bromo-6-methylpyridine-2-carbonitrile (1173897-86-3)

Guidance literature:

In acetonitrile; at 80 ℃; for 16h; Inert atmosphere;

Reference yield: 77.0%

copper(I) cyanide (544-92-3) + 2,5-dibromo-6-methylpyridine (39919-65-8) → 5-bromo-6-methylpyridine-2-carbonitrile (1173897-86-3)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 2h;

upstream raw materials:

2,5-dibromo-6-methylpyridine

zinc(II) cyanide

sodium cyanide

3-bromo-1-methoxy-2-methylpyridinium methyl sulfate

Downstream raw materials:

ethyl 5-bromo-6-methylpyridine-2-carboxylate

5-bromo-6-methylpicolinamide

1-ethyl-7-(2-methyl-6-(4H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

5-cyclopropyl-6-(4-fluorobenzyl)pyridine-2-carboxylic acid

Refernces

• 1、 Ni?o, Patricia,Caba, Marta,Aguilar, Nuria,Terricabras, Emma,Albericio, Fernando,Fernàndez, Joan-Carles. "Povarov reaction, scope and limitations: Preparation of diversely heterocyclic tetrahydro-1H-cyclopenta[c]quinolines". . p. 1117 - 1130. Retrieved 2017/04/28.
• 2、 Mortensen, Deborah S.,Perrin-Ninkovic, Sophie M.,Shevlin, Graziella,Zhao, Jingjing,Packard, Garrick,Bahmanyar, Sogole,Correa, Matthew,Elsner, Jan,Harris, Roy,Lee, Branden G. S.,Papa, Patrick,Parnes, Jason S.,Riggs, Jennifer R.,Sapienza, John,Tehrani, Lida,Whitefield, Brandon,Apuy, Julius,Bisonette, René R.,Gamez, James C.,Hickman, Matt,Khambatta, Godrej,Leisten, Jim,Peng, Sophie X.,Richardson, Samantha J.,Cathers, Brian E.,Canan, Stacie S.,Moghaddam, Mehran F.,Raymon, Heather K.,Worland, Peter,Narla, Rama Krishna,Fultz, Kimberly E.,Sankar, Sabita. "Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223". supporting information. p. 5323 - 5333. Retrieved 2015/08/03.