Technology Process of 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-(3,4,5-trihydroxyoxan-2-yl)chromen-4-one
There total 23 articles about 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-(3,4,5-trihydroxyoxan-2-yl)chromen-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; sodium methylate;
at 0 ℃;
for 5h;
pH=9 - 10;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 4.5 h / 25 °C / Inert atmosphere; Molecular sieve; Cooling
2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C
3: ammonium cerium (IV) nitrate / water; acetonitrile / 3 h / 20 °C
4: dipyridinium dichromate / dichloromethane / 4 h / 40 °C
5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 20 °C
6: pyridine / 50 °C
7: iodine; dimethyl sulfoxide / 4 h / 140 °C
8: sodium methylate / methanol / 20 °C / pH Ca. 9 - Ca. 10
With
pyridine; dipyridinium dichromate; ammonium cerium (IV) nitrate; trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; iodine; sodium methylate; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2021.132216
