2-(trifluoromethyl)-6-iodopyridine

Base Information

• Chemical Name: 2-(trifluoromethyl)-6-iodopyridine
• CAS No.: 100366-74-3
• Molecular Formula: C6H3F3IN
• Molecular Weight: 272.996
• Hs Code.: 2933399090
• Mol file: 100366-74-3.mol

Synonyms:2-(Trifluoromethyl)-6-iodopyridine

Chemical Property of 2-(trifluoromethyl)-6-iodopyridine

Chemical Property:

• Vapor Pressure: 0.345mmHg at 25°C
• Boiling Point: 206.2ºC at 760 mmHg
• Flash Point: 78.5ºC
• PSA: 12.89000
• Density: 1.974g/cm3
• LogP: 2.70500
• Storage Temp.: Refrigerated.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Iodo-6-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(trifluoromethyl)-6-iodopyridine

There total 1 articles about 2-(trifluoromethyl)-6-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-chloro-6-trifluoromethylpyridine (39890-95-4) → 2-iodo-6-(trifluoromethyl)pyridine (100366-74-3)

Guidance literature:

With hydrogen iodide; sodium iodide; for 24h; Heating;

DOI:10.1021/jo00356a043

Reference yield: 88.0%

(E)-2,4-dichloro-6-hydroxybenzaldehyde O-butyl oxime + 2-iodo-6-(trifluoromethyl)pyridine (100366-74-3) → (E)-2,4-dichloro-6-hydroxybenzaldehyde O-(2-(6-(trifluoromethyl)pyridin-2-yl)propyl)oxime

Guidance literature:

With 3-nitro-5-(trifluoromethyl)pyridin-2(1H)-one; palladium diacetate; silver trifluoroacetate; at 100 ℃; for 12h; Sealed tube;

DOI:10.1002/anie.202000632

Reference yield: 84.0%

tert-butyl ((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)(m-tolyl)carbamate + 2-iodo-6-(trifluoromethyl)pyridine (100366-74-3) → tert-butyl ((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-(3-methyl-5-(6-(trifluoromethyl)pyridin-2-yl)-phenyl)carbamate

Guidance literature:

With N-(2-hydroxypyridin-3-yl)acetamide; methyl bicyclo[2.2.1]hept-2-ene-2-carboxylate; silver(I) acetate; palladium diacetate; In 1,2-dichloro-ethane; at 100 ℃; for 24h;

DOI:10.1021/jacs.6b04966

upstream raw materials:

2-chloro-6-trifluoromethylpyridine

Refernces