6-Bromo-2-chloronicotinaldehyde

Base Information

• Chemical Name: 6-Bromo-2-chloronicotinaldehyde
• CAS No.: 1125410-08-3
• Molecular Formula: C₆H₃BrClNO
• Molecular Weight: 220.453
• Hs Code.: 2933399090
• Mol file: 1125410-08-3.mol

Synonyms:3-Pyridinecarboxaldehyde, 6-bromo-2-chloro-;

Chemical Property of 6-Bromo-2-chloronicotinaldehyde

Chemical Property:

• Boiling Point: 310 °C at 760 mmHg
• Flash Point: 141.3 °C
• PSA: 29.96000
• Density: 1.8 g/cm³
• LogP: 2.31000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-2-chloronicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2-chloronicotinaldehyde

There total 3 articles about 6-Bromo-2-chloronicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

6-bromo-2-chloropyridine-3-carboxylic acid (1060815-67-9) → 6-bromo-2-chloronicotinaldehyde (1125410-08-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

ethyl 2-chloronicotinate (1452-94-4) → 6-bromo-2-chloronicotinaldehyde (1125410-08-3)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid; dihydrogen peroxide / water / 70 °C

2: phosphorus(V) oxybromide / acetonitrile / 20 °C

3: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -75 °C

4: Dess-Martin periodane / dichloromethane / 20 °C

With dihydrogen peroxide; diisobutylaluminium hydride; Dess-Martin periodane; trifluoroacetic acid; phosphorus(V) oxybromide; In dichloromethane; water; toluene; acetonitrile;

Reference yield:

ethyl 2-chloronicotinate-N-oxide (164464-49-7) → 6-bromo-2-chloronicotinaldehyde (1125410-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / acetonitrile / 20 °C

2: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -75 °C

3: Dess-Martin periodane / dichloromethane / 20 °C

With diisobutylaluminium hydride; Dess-Martin periodane; phosphorus(V) oxybromide; In dichloromethane; toluene; acetonitrile;

upstream raw materials:

ethyl 2-chloronicotinate

ethyl 2-chloronicotinate-N-oxide

6-bromo-2-chloropyridine-3-carboxylic acid

Downstream raw materials:

5-(11‘-fluoro-6’H-spiro[cyclopropane-1,5‘-indolo[1,2-h][1,7]naphthyridin]-2‘-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

5-(6-chloro-5-(1-(hydroxymethyl)cyclopropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Refernces