5-hydroxy-2-pyrrolidone

Base Information

• Chemical Name: 5-hydroxy-2-pyrrolidone
• CAS No.: 62312-55-4
• Molecular Formula: C4H7 N O2
• Molecular Weight: 101.105
• Mol file: 62312-55-4.mol

Synonyms:2-Pyrrolidinone,5-hydroxy-, (?à)-;(?à)-5-Hydroxy-2-pyrrolidone;5-Hydroxy-2-pyrrolidone; 5-Hydroxypyrrolidin-2-one; DL-5-Hydroxy-2-pyrrolidone

Chemical Property of 5-hydroxy-2-pyrrolidone

Chemical Property:

• Vapor Pressure: 9.26E-07mmHg at 25°C
• Melting Point: 98-99 °C
• Boiling Point: 363.6°C at 760 mmHg
• PKA: 12.92±0.20(Predicted)
• Flash Point: 173.7°C
• PSA: 49.33000
• Density: 1.292g/cm³
• LogP: -0.45640
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

5-Hydroxy-2-Pyrrolidinone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-hydroxy-2-pyrrolidone

There total 3 articles about 5-hydroxy-2-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-methoxy-dihydro-furan-2-one (21963-36-0) → rac-4-hydroxy-2-pyrrolidone (62312-55-4,168111-92-0)

Guidance literature:

With ammonium hydroxide; Ambient temperature;

Reference yield: 60.0%

5-ethoxy-pyrrolidin-2-one (39662-63-0) → rac-4-hydroxy-2-pyrrolidone (62312-55-4,168111-92-0)

Guidance literature:

In water; for 3h; Reflux;

DOI:10.1016/j.tet.2015.10.020

Reference yield:

→ rac-4-hydroxy-2-pyrrolidone (62312-55-4,168111-92-0)

Guidance literature:

/BRN= 448341/, OsO4, NaIO4;

upstream raw materials:

5-methoxy-dihydro-furan-2-one

5-ethoxy-pyrrolidin-2-one

Downstream raw materials:

5-chloro-1H-pyrrole-2-carboxaldehyde

5-chloropyrrole-2,4-dicarboxaldehyde

5-methoxypyrrolidin-2-one

5-benzyloxy-2-pyrrolidinone

Refernces

• 1、 Farina, Francisco,Martin, M. Victoria,Paredes, M. Carmen,Ortega, M. Carmen,Tito, Amelia. "PSEUDOESTERS AND DERIVATIVES. XXII. SYNTHESIS OF 5-HYDROXY-3-PYRROLIN-2-ONES AND 5-HYDROXYPYRROLIDIN-2-ONES BY AMMONOLYSIS OF 5-METHOXYFURAN-2(5H)-ONES AND DERIVATIVES". . p. 1733 - 1739. Retrieved 2007/10/02.