Technology Process of Flurbiprofen axetil
There total 6 articles about Flurbiprofen axetil which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
tetrahydrofuran;
at 50 ℃;
for 12h;
- Guidance literature:
-
In
tetrahydrofuran;
at 15 - 70 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 62 - 72 °C
1.2: 4 h / 25 - 72 °C / Cooling with ice
2.1: sodium hydroxide / Reflux
3.1: potassium carbonate / tetrahydrofuran / 0.5 h / 25 °C
4.1: tetrahydrofuran / 15 - 70 °C
With
iodine; potassium carbonate; magnesium; sodium hydroxide;
In
tetrahydrofuran;
1.1: |Grignard Reaction;
