Angiotensin amide

Base Information

• Chemical Name: Angiotensin amide
• CAS No.: 53-73-6
• Molecular Formula: C49H70 N14 O11
• Molecular Weight: 1031.18
• European Community (EC) Number: 200-182-3
• NSC Number: 107678
• Wikipedia: Angiotensinamide
• Mol file: 53-73-6.mol

Synonyms:1 Asparagine 5 valine Angiotensin II;1-Asparagine-5-valine Angiotensin II;5 Valine Angiotensin II Amide;5-Valine-Angiotensin II Amide;Amide, 5-Valine-Angiotensin II;Amide, Angiotensin;Angiotensin Amide;Angiotensin II, 1-Asparagine-5-valine;Angiotensinamide;Hypertensin

Chemical Property of Angiotensin amide

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 3.56±0.10(Predicted)
• Flash Point: °C
• PSA: 412.13000
• Density: 1.45g/cm³
• LogP: 2.78040
• Storage Temp.: -15°C
• XLogP3: -2.7
• Hydrogen Bond Donor Count: 13
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 28
• Exact Mass: 1030.53484910
• Heavy Atom Count: 74
• Complexity: 1960

Purity/Quality:

99% ^*data from raw suppliers

[Asn1, Val5]-Angiotensin II ≥97% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)C)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)N)N

Technology Process of Angiotensin amide

There total 5 articles about Angiotensin amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ angiotensinamide (53-73-6)

Guidance literature:

Reference yield:

Fmoc-Val-OH (68858-20-8) + Fmoc-Pro-OH (71989-31-6) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + L-Asn(Trt) (132388-59-1) + Fmoc-His(Trt)-OH (109425-51-6) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → Asn-Arg-Val-Tyr-Val-His-Pro-Phe (53-73-6)

Guidance literature:

N-Fmoc L-Phe; With N-ethyl-N,N-diisopropylamine; at 90 ℃; for 0.0833333h; Automated synthesizer;

With pyrrolidine; at 95 ℃; for 0.0138889h;

Fmoc-Val-OH; Fmoc-Pro-OH; Fmoc-Tyr(tBu)-OH; L-Asn(Trt); Fmoc-His(Trt)-OH; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

Reference yield:

→ Asn-Arg-Val-Tyr-Val-His-Pro-Phe (53-73-6)

Guidance literature:

With water; potassium carbonate; Hydrolysis;

DOI:10.1002/hlca.19580410512

upstream raw materials:

Fmoc-Val-OH

Fmoc-Pro-OH

N-Fmoc L-Phe

Fmoc-Tyr(tBu)-OH

Downstream raw materials:

6-(p-chlorophenyl)-3-chloropyridazine

Refernces

• 1、 -. "IMPROVEMENTS IN SOLID PHASE PEPTIDE SYNTHESIS". Paragraph 0071-0076. . Retrieved 2017/08/01.