Guanethidine

Base Information Edit

Chemical Name:Guanethidine
CAS No.:55-65-2
Molecular Formula:C10H22 N4
Molecular Weight:198.311
Hs Code.:
European Community (EC) Number:200-241-3
UNII:ZTI6C33Q2Q
DSSTox Substance ID:DTXSID5023116
Nikkaji Number:J4.562D
Wikipedia:Guanethidine
Wikidata:Q420673
NCI Thesaurus Code:C65830
Pharos Ligand ID:XSVDCUPXXRUS
Metabolomics Workbench ID:43388
ChEMBL ID:CHEMBL765
Mol file:55-65-2.mol

Synonyms:((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine;Guanethidine;Guanethidine Monosulfate;Guanethidine Sulfate;Guanethidine Sulfate (1:1);Guanethidine Sulfate (1:2);Guanethidine Sulfate (2:1);Guanethidine Sulfate (2:1), 14C-Labeled;Ismelin;Isobarin;Monosulfate, Guanethidine;Octadine;Oktadin;Sulfate, Guanethidine

Suppliers and Price of Guanethidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
GUANETHIDINE 95.00%
100MG
$ 1259.35

Total 14 raw suppliers

Chemical Property of Guanethidine Edit

Chemical Property:

Vapor Pressure:6.09E-05mmHg at 25°C
Refractive Index:1.4910 (estimate)
Boiling Point:345.6°Cat760mmHg
PKA:pKa 11.4 (Uncertain)
Flash Point:162.8°C
PSA：65.14000
Density:1.13g/cm³
LogP:1.86440
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:198.18444672
Heavy Atom Count:14
Complexity:167

Purity/Quality:

98%,99%, ^*data from raw suppliers

GUANETHIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCCN(CCC1)CCN=C(N)N
Recent EU Clinical Trials:En proof of concept (POC) studie g?llande guanethidines sm?rtlindrande effekt vid regional i.v administrering f?r behandling av komplext regional sm?rtsyndrom (CRP)
Description Guanethidine is used for severe hypertension when the use of the more generally accepted drugs turns out to be unsuccessful. It is a powerful, long-lasting antihypertensive drug; however, it affects a patient’s blood pressure only in the orthostatic position, and not when lying down. Guanethidine is a very powerful and long-lasting drug, and its action often lasts 2–3 days after its use has been stopped.
Uses Antihypertensive.
Therapeutic Function Antihypertensive
Biological Functions Guanethidine (Ismelin) is a powerful antihypertensive agent that is quite effective in the treatment of moderate to severe hypertension. It is most frequently used in the treatment of severe hypertension that is resistant to other agents. Guanethidine exerts its effects at peripheral sympathetic nerve endings following its active transport into the nerve varicosities by the neuronal amine transport system. This is the same uptake system that transports norepinephrine into the varicosity).The accumulation of guanethidine in adrenergic neurons, through an as yet unexplained mechanism, disrupts the process by which action potentials trigger the release of stored norepinephrine and other cotransmitters from nerve terminals. It is this action of guanethidine that is primarily responsible for its antihypertensive properties. Parasympathetic function is not altered, a fact that distinguishes guanethidine from the ganglionic blocking agent. Guanethidine is suitable for oral use, and this is its usual route of administration. However, absorption from the gastrointestinal tract is variable. The half-life of guanethidine is 5 days, with about one-seventh of the total administered dose eliminated per day. The slow elimination contributes to the cumulative and prolonged effects of the drug. Guanethidine reduces blood pressure by its ability to diminish vascular tone; both the arterial and venous sides of the circulatory system are involved. The resulting venous pooling contributes to orthostatic hypotension, a prominent feature of guanethidine treatment. The reduction in blood pressure is more prominent when the patient is standing than recumbent.

Technology Process of Guanethidine

There total 2 articles about Guanethidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: