Tomelukast

Base Information Edit

Chemical Name:Tomelukast
CAS No.:88107-10-2
Molecular Formula:C16H22N4O3
Molecular Weight:318.376
Hs Code.:
European Community (EC) Number:635-828-7
UNII:59762X5CLS
DSSTox Substance ID:DTXSID7020344
Nikkaji Number:J22.986E
Wikidata:Q27145209
NCI Thesaurus Code:C74135
ChEMBL ID:CHEMBL162358
Mol file:88107-10-2.mol

Synonyms:1-((2-hydroxy-3-propyl)-4-(1H-tetrazol-5-yl)butoxyphenyl)ethanone;Lilly 171883;LY 171883;LY-171883;LY171883

Suppliers and Price of Tomelukast

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LY171883
25mg
$ 130.00

TRC
LY171883
10mg
$ 65.00

Cayman Chemical
LY171883 ≥98%
10mg
$ 61.00

Cayman Chemical
LY171883 ≥98%
5mg
$ 32.00

Cayman Chemical
LY171883 ≥98%
50mg
$ 256.00

Cayman Chemical
LY171883 ≥98%
100mg
$ 448.00

ApexBio Technology
LY171883
50mg
$ 355.00

ApexBio Technology
LY171883
100mg
$ 622.00

ApexBio Technology
LY171883
10mg
$ 84.00

American Custom Chemicals Corporation
5-[4-(1-ACETYL-2-HYDROXY-3-PROPYLPHENOXY)BUTYL]-1H-TETRAZOLE 95.00%
100MG
$ 1166.67

Total 13 raw suppliers

Chemical Property of Tomelukast Edit

Chemical Property:

Vapor Pressure:7.73E-13mmHg at 25°C
Melting Point:117-119℃
Refractive Index:1.574
Boiling Point:553 °C at 760 mmHg
PKA:5.02±0.10(Predicted)
Flash Point:288.3 °C
PSA：100.99000
Density:1.22 g/cm³
LogP:2.46210
Storage Temp.:Store at +4°C
Solubility.:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml),
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:318.16919058
Heavy Atom Count:23
Complexity:369

Purity/Quality:

99% ^*data from raw suppliers

LY171883 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22
Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCC1=C(C=CC(=C1O)C(=O)C)OCCCCC2=NNN=N2
Description LY-171883 (88107-10-2) is a selective and orally active leukotriene D4 (LTD4) antagonist (Ki = 0.63 μM).1 It is also an activator of peroxisome proliferator-activated receptors (PPARs).2,3
Uses LY 171883 is a selective leukotriene D4 antagonist.

Technology Process of Tomelukast

There total 3 articles about Tomelukast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%