PANCREATIC POLYPEPTIDE, HUMAN

Base Information

• Chemical Name: PANCREATIC POLYPEPTIDE, HUMAN
• CAS No.: 75976-10-2
• Molecular Formula: C185H287 N53 O54 S2
• Molecular Weight: 442.3
• Mol file: 75976-10-2.mol

Synonyms:Pancreaticpolypeptide (rat), 6-L-valine-11-L-asparagine-14-L-proline-17-L-methionine-21-L-alanine-22-L-alanine-23-L-asparticacid-30-L-methionine-; 3: PN: WO2005089786 SEQID: 3 claimed protein; 3: PN:WO2005089789 SEQID: 3 claimed protein; 3: PN: WO2005089790 SEQID: 3 claimedprotein; 5: PN: WO2007038943 SEQID: 3 claimed protein; Human pancreaticpolypeptide; L-Tyrosinamide, L-alanyl-L-prolyl-L-leucyl-L-a-glutamyl-L-prolyl-L-valyl-L-tyrosyl-L-prolylglycyl-L-a-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-a-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-alanyl-L-a-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-leucyl-L-threonyl-L-arginyl-L-prolyl-L-arginyl-;pancreatic polypeptide (human)

Chemical Property of PANCREATIC POLYPEPTIDE, HUMAN

Chemical Property:

• Storage Temp.: -15°C

Purity/Quality:

98%min ^*data from raw suppliers

PancreaticPolypeptide,human ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Biological functions: PP secreted from the pancreas stimulates gastric juice secretion. The peripheral administration of PP decreases food intake in rodents while central administration of PP increases food intake. PP inhibits pancreatic exocrine secretion, gall bladder contraction, gastric emptying, and?gutmotility.The peripheral administration of PP causes Y4 receptor-dependent c-Fos expression in the brainstem, hypothalamus, and amygdala. The chronic peripheral administration of PP reduces anxiety.
• Description: Pancreatic polypeptide is an agonist of neuropeptide Y (NPY) receptors that reduces forskolin-induced cAMP accumulation in L-M(TK-) cells recombinantly expressing human and rat Y4 receptors (EC50s = 87.1 and 36.3 pM, respectively). It binds to Y1 and Y5 receptors with Ki values of 19 and 3.9 nM, respectively, for human and 50 and 2.4 nM, respectively, for rhesus monkey receptors. Pancreatic polypeptide also binds to rabbit Y1, Y2, Y4, and Y5 receptors (Kis = 0.39, 0.087, 0.79, and 0.24 nM, respectively). It induces contractile responses in isolated rat colon with EC50 values of 1.6 and 0.7 nM for ascending and descending colon segments, respectively. In vivo, pancreatic polypeptide (0.7-7 nmol, i.c.v.) increases food intake in rats.
• Clinical Use: PP secretion from the pancreas in response to vagal nerve stimulation has been used as a diagnostic test of vagal nerve function.