Hydrocortisone aceponate

Base Information

• Chemical Name: Hydrocortisone aceponate
• CAS No.: 74050-20-7
• Molecular Formula: C₂₆H₃₆O₇
• Molecular Weight: 460.568
• European Community (EC) Number: 658-089-2
• UNII: 2340UP1L2G
• Nikkaji Number: J563.426A
• Wikipedia: Hydrocortisone_aceponate
• Wikidata: Q15409432
• NCI Thesaurus Code: C90952
• Metabolomics Workbench ID: 154943
• ChEMBL ID: CHEMBL2106309
• Mol file: 74050-20-7.mol

Synonyms:21-(acetyloxy)-11beta-hydroxy-17alpha-(propionyloxy)-4-pregnene-3,20-dione;hydrocortisone aceponate

Chemical Property of Hydrocortisone aceponate

Chemical Property:

• Vapor Pressure: 2.41E-16mmHg at 25°C
• Melting Point: 144-146°C
• Boiling Point: 589.3°C at 760 mmHg
• Flash Point: 192.4°C
• PSA: 106.97000
• Density: 1.23±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 3.31330
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 460.24610348
• Heavy Atom Count: 33
• Complexity: 906

Purity/Quality:

95-99% ^*data from raw suppliers

Hydrocortisone17-Propionate21-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)C(=O)COC(=O)C
• Isomeric SMILES: CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)COC(=O)C
• Description: Hydrocortisone aceponate is the 17-a-propionate derivative of hydrocortisone-21-acetate. Its is reportedly significantly superior to the latter in the treatment of dermatoses of varying severity.
• Uses: A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. Glucocorticosteroid. A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. Glucocorticosteroid

Technology Process of Hydrocortisone aceponate

There total 1 articles about Hydrocortisone aceponate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Hydrocortison-17-propionat-21-acetat (74050-20-7)

Guidance literature:

aus Hydrocortison-17-propionat + Ac2O + Pyridin;