Monosodium urate (crystals)

Base Information

• Chemical Name: Monosodium urate (crystals)
• CAS No.: 1198-77-2
• Molecular Formula: C5H4 N4 O3 . Na
• Molecular Weight: 190.094
• Hs Code.: 2933990090
• European Community (EC) Number: 214-838-1
• Mol file: 1198-77-2.mol

Synonyms:Uric acid sodium salt;1198-77-2;NCGC00181049-01;Monosodium urate (crystals);CID 16220071;SCHEMBL229866;XDKLKFULWJYRCB-UHFFFAOYSA-N;Uric acid monosodium salt (crystals);AS-80123

Chemical Property of Monosodium urate (crystals)

Chemical Property:

• Appearance/Colour: solid /WHITE TO WHITE WITH YELLOW CAST POWDER
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 117.46000
• Density: g/cm³
• LogP: -0.91670
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 191.01810928
• Heavy Atom Count: 13
• Complexity: 332

Purity/Quality:

98%,99%, ^*data from raw suppliers

Monosodium urate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C12=C(NC(=O)N1)NC(=O)NC2=O.[Na]
• Description: Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase. The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide. Uric acid acts as a potent peroxynitrite scavenger and antioxidant. However, high levels of serum uric acid (>120 μg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease. Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.
• Uses: Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

Technology Process of Monosodium urate (crystals)

There total 2 articles about Monosodium urate (crystals) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

uric Acid (69-93-2) → monosodium urate crystal (1198-77-2)

Guidance literature:

With sodium hydroxide; at 70 ℃; for 24h; pH=8-9;

Reference yield:

→ monosodium urate crystal (1198-77-2)

Guidance literature:

upstream raw materials:

uric Acid

Refernces

• 1、 Kiyani, Mubin Mustafa,Butt, Maisra Azhar,Rehman, Hamza,Mustafa, Moheen,Sajjad, Abdul Ghafoor,Shah, Syed Sajid Hussain,Mahmood, Tariq,Bokhari, Syed Ali Imran. "Evaluation of Antioxidant Activity and Histopathological Changes Occurred by the Oral Ingestion of CuO Nanoparticles in Monosodium Urate Crystal-Induced Hyperuricemic BALB/c Mice". . p. 217 - 227. Retrieved 2022.
• 2、 -. "Treatment of gout". Page/Page column 23. . Retrieved 2016/08/29.