Gefitinib N-Oxide

Base Information

• Chemical Name: Gefitinib N-Oxide
• CAS No.: 847949-51-3
• Molecular Formula: C₂₂H₂₄ClFN₄O₄
• Molecular Weight: 462.908
• Mol file: 847949-51-3.mol

Synonyms:Gefitinib N-Oxide;Gefitinib Morpholine N-oxide;

Chemical Property of Gefitinib N-Oxide

Chemical Property:

• PSA: 94.93000
• LogP: 4.32000

Purity/Quality:

NLT 98% ^*data from raw suppliers

GefitinibMorpholineN-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Gefitinib Morpholine N-oxide is the N-oxide derivative of Gefitinib (G304000); a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR).

Technology Process of Gefitinib N-Oxide

There total 1 articles about Gefitinib N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

gefitinib (184475-35-2) → 4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine 4-oxide (847949-51-3) + 4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxy-1-oxidoquinazolin-6-yl)oxy)propyl)morpholine 4-oxide

Guidance literature:

gefitinib; With sodium hydroxide; for 24h; Reflux;

With dihydrogen peroxide;

DOI:10.14233/ajchem.2021.23210

upstream raw materials:

gefitinib

Refernces