4-Ethoxycinnamic Acid

Base Information

• Chemical Name: 4-Ethoxycinnamic Acid
• CAS No.: 2373-79-7
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 29189900
• European Community (EC) Number: 640-430-1
• Nikkaji Number: J277.934J,J2.181.761I
• Mol file: 2373-79-7.mol

Synonyms:4-Ethoxycinnamic Acid;2373-79-7;3-(4-Ethoxyphenyl)acrylic acid;(2E)-3-(4-ethoxyphenyl)prop-2-enoic acid;151539-70-7;(E)-3-(4-ethoxyphenyl)prop-2-enoic acid;(E)-3-(4-ethoxyphenyl)acrylic acid;MFCD00016848;p-ethoxycinnamic acid;3-(4-ethoxyphenyl)prop-2-enoic acid;p-Ethoxy cinnamic acid;4-Ethoxycinnamic acid, predominantly trans;(E)-3-(4-ethoxyphenyl)-2-propenoic acid;SCHEMBL691131;JS-183C;(E)-3-(4-ethoxyphenyl)acrylicacid;BBL037212;STK501190;AKOS000263507;EN300-11185;EN300-832890;4-Ethoxycinnamic acid, predominantly trans, 97%;A816926;SR-01000597154;J-501916;SR-01000597154-1;Z2315575657

Chemical Property of 4-Ethoxycinnamic Acid

Chemical Property:

• Vapor Pressure: 1.34E-05mmHg at 25°C
• Melting Point: 195-199 °C(lit.)
• Boiling Point: 353.2 °C at 760 mmHg
• PKA: 4.61±0.10(Predicted)
• Flash Point: 139.2 °C
• PSA: 46.53000
• Density: 1.161 g/cm³
• LogP: 2.18310
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

99% ^*data from raw suppliers

4-Ethoxycinnamic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37/39-22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)C=CC(=O)O
• Isomeric SMILES: CCOC1=CC=C(C=C1)/C=C/C(=O)O

Technology Process of 4-Ethoxycinnamic Acid

There total 26 articles about 4-Ethoxycinnamic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-methyl-3-(4-ethoxyphenyl)prop-2-enoate (87711-71-5) → (E)-4-ethoxycinnamic acid (2373-79-7)

Guidance literature:

With water; potassium carbonate; In methanol; for 3h; Reflux;

DOI:10.1021/jm101510d

Reference yield: 99.5%

malonic acid (141-82-2) + 4-ethoxybenzaldehyde (10031-82-0) → (E)-4-ethoxycinnamic acid (2373-79-7)

Guidance literature:

With piperidine; pyridine; at 120 ℃; for 4.5h;

DOI:10.1039/c3ob40199e

Reference yield: 90.0%

5-((4-ethoxyphenyl)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (741272-25-3) → (E)-4-ethoxycinnamic acid (2373-79-7)

Guidance literature:

With iron(III) chloride hexahydrate; water; In nitromethane; for 0.05 - 0.0833333h; stereoselective reaction; Sealed tube; Microwave irradiation;

DOI:10.1021/ol402130t

upstream raw materials:

malonic acid

4-ethoxybenzaldehyde

bromine

benzene

Downstream raw materials:

(E)-ethyl 3-(4-ethoxyphenyl)acrylate

(E)-N'-[3-(4-ethoxyphenyl)propenoyl]isonicotinohydrazide

(2E,N',E)-3-(4-ethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

(E)-3-(4-ethoxystyryl)-[1,2,4]triazolo[3,4-α]phthalazine

Refernces

• 1、 Ranchchh, Avani R.,Chavda, Kavita,Bhanderi, Roshani,Patel, Suman,Bhoya. "Mesomorphism dependence on central bridge and tail ended polar group". . p. 33 - 42. Retrieved 2019/02/24.
• 2、 Ranchchh, Avani R.,Tharesha, Bhavna R.,Bhoya. "“Dependence of Mesomorphism in Combination with Fluoro and Chloro Groups”". . p. 49 - 58. Retrieved 2019/07/03.