4-broMo-1-(2-Methoxyethyl)-1H-pyrazole

Base Information

• Chemical Name: 4-broMo-1-(2-Methoxyethyl)-1H-pyrazole
• CAS No.: 847818-49-9
• Molecular Formula: C6H9BrN2O
• Molecular Weight: 205.054
• Mol file: 847818-49-9.mol

Synonyms:

Chemical Property of 4-broMo-1-(2-Methoxyethyl)-1H-pyrazole

Chemical Property:

• Boiling Point: 253.3±20.0 °C(Predicted)
• PKA: -0.01±0.10(Predicted)
• PSA: 27.05000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 1.29200
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-bromo-1-(2-methoxyethyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-broMo-1-(2-Methoxyethyl)-1H-pyrazole

There total 2 articles about 4-broMo-1-(2-Methoxyethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-bromo-1H-pyrazole (2075-45-8) + 2-Bromoethyl methyl ether (6482-24-2) → 4-bromo-1-(2-methoxyethyl)-1H-pyrazole (847818-49-9)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃;

Reference yield: 74.0%

4-bromo-1H-pyrazole (2075-45-8) + 2-chloroethyl methyl ether (627-42-9) → 4-bromo-1-(2-methoxyethyl)-1H-pyrazole (847818-49-9)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 20 - 30 ℃; for 18h; Inert atmosphere;

Reference yield: 88.42%

3-fluoro-4-methoxycarbonylphenylboronic acid (505083-04-5) + 4-bromo-1-(2-methoxyethyl)-1H-pyrazole (847818-49-9) → methyl 2-fluoro-4-[1-(2-methoxyethyl)pyrazol-4-yl]benzoate

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; at 100 ℃; for 5h; Inert atmosphere;

upstream raw materials:

4-bromo-1H-pyrazole

2-Bromoethyl methyl ether

2-chloroethyl methyl ether

Downstream raw materials:

1-(2-methoxyethyl)-1H-pyrazol-4-ylboronic acid

1-(2-methoxyethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Refernces

• 1、 -. "CONDENSED-CYCLIC COMPOUND". Paragraph 0396. . Retrieved 2021/08/05.
• 2、 -. "Pyrazole N-alkylation method". Paragraph 0037; 0038. . Retrieved 2018/12/14.