Proflavine hemisulfate

Base Information

• Chemical Name: Proflavine hemisulfate
• CAS No.: 1811-28-5
• Molecular Formula: C13H11N3•¹/2H2O4S
• Molecular Weight: 307.33
• Hs Code.: 2933990090
• European Community (EC) Number: 209-038-4,217-320-3
• NSC Number: 759900,689004,6095,1510
• UNII: 2961Y60ATP
• DSSTox Substance ID: DTXSID90203821
• Wikidata: Q27254392
• NCI Thesaurus Code: C76758
• RXCUI: 8724
• ChEMBL ID: CHEMBL1964546
• Mol file: 1811-28-5.mol

Synonyms:3,6 Diamino Acridine;3,6 Diaminoacridine;3,6-diamino acridine;3,6-diaminoacridine;Acridine, 3,6-Diamino;Hemisulfate, Proflavine;Proflavin;Proflavine;Proflavine Hemisulfate

Chemical Property of Proflavine hemisulfate

Chemical Property:

• Appearance/Colour: orange to red powder.
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 284-286oC
• Boiling Point: 506.9 °C at 760 mmHg
• Flash Point: 292.9 °C
• PSA: 64.93000
• Density: 1.346 g/cm³
• LogP: 3.71480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 0
• Exact Mass: 307.06267708
• Heavy Atom Count: 21
• Complexity: 313

Purity/Quality:

98%,99%, ^*data from raw suppliers

Proflavine Hemisulfate Hydrate >97.0%(N) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Biocides/Disinfectants
• Canonical SMILES: C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.OS(=O)(=O)O
• Recent ClinicalTrials: Precision Optical Guidance for Oral Biopsy
• Uses: antiseptic An Acridine derivative with limited antifungal activity Proflavine Hemisulfate is used in preparation of Adenine and Adenine nucleotides via photochemical demethylation of methyladenines.

Technology Process of Proflavine hemisulfate

There total 2 articles about Proflavine hemisulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-diamino-10-methyl-9,10-dihydro-acridine-9-carbonitrile → 3,6-diaminoacridine sulfate (1811-28-5)

Guidance literature:

With sulfuric acid;

Reference yield:

acriflavine (86-40-8) → 3,6-diaminoacridine sulfate (1811-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: natrium carbonate / 75 °C

2: H₂SO₄

With sulfuric acid; sodium carbonate;

Reference yield:

benzophenone (119-61-9) + proflavin (553-30-0,1811-28-5,3237-53-4) → N,N'-Dibenzhydrylidene-acridine-3,6-diamine (135691-57-5)

Guidance literature:

With ammonia; In water; for 3h; Heating;

upstream raw materials:

acriflavine

Downstream raw materials:

N,N'-Dibenzhydrylidene-acridine-3,6-diamine

N³,N⁶-bis-(4-methoxy-benzyliden)-acridine-3,6-diyldiamine