Ginkgolide M

Base Information

• Chemical Name: Ginkgolide M
• CAS No.: 15291-78-8
• Molecular Formula: C₂₀H₂₄O₁₀
• Molecular Weight: 424.405
• Metabolomics Workbench ID: 126894
• Pharos Ligand ID: BRKAV875RZRK
• Wikidata: Q105139197
• Mol file: 15291-78-8.mol

Synonyms:ginkgolide M

Chemical Property of Ginkgolide M

Chemical Property:

• Refractive Index: 1.674
• Boiling Point: 783.7 °C at 760 mmHg
• PKA: 12.10±0.70(Predicted)
• Flash Point: 282 °C
• PSA: 148.82000
• Density: 1.69 g/cm³
• LogP: -1.51360
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 1
• Exact Mass: 424.13694696
• Heavy Atom Count: 30
• Complexity: 910

Purity/Quality:

99% ^*data from raw suppliers

GINKGOLIDEM 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C2C(C(C34C25C(=O)OC3C(C(C46C(C(=O)OC6O5)O)C(C)(C)C)O)O)OC1=O

Technology Process of Ginkgolide M

There total 16 articles about Ginkgolide M which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1,7,10-Trihydroxy-14-epiginkgolid (153541-09-4,15291-78-8) → ginkgolide M (15291-78-8)

Guidance literature:

With dmap; In water; acetonitrile; for 96h; Heating;

Reference yield:

3,14-dehydro-10-benzyl-ginkgolide C → 14-epi-ginkgolide M (15291-78-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 18h; under 31029.7 Torr;

Reference yield:

14-epi-ginkgolide M (15291-78-8) → ginkgolide M (15291-78-8)

Guidance literature:

With dmap; In water; acetonitrile; at 80 ℃; for 96h; Sealed tube;

upstream raw materials:

1,7,10-Trihydroxy-14-epiginkgolid

1,3,7,10-Tetrahydroxyginkgolid

7-Acetoxy-1,10-dihydroxy-3,14-didehydroginkgolid

7-Acetoxy-1,10-dihydroxy-14-epiginkgolid

Refernces

• 1、 Bolshakov, Sergei,Dzyuba, Sergei V.,Decatur, John,Nakanishi, Koji. "A concise synthesis of ginkgolide M, a minor component of a terpene trilactone fraction from Ginkgo biloba roots". . p. 429 - 431. Retrieved 2008/09/19.