1-Chloro-2,2-difluoropropane

Base Information

• Chemical Name: 1-Chloro-2,2-difluoropropane
• CAS No.: 420-99-5
• Molecular Formula: C3H5ClF2
• Molecular Weight: 114.523
• Hs Code.: 2903791090
• DSSTox Substance ID: DTXSID40194811
• Nikkaji Number: J100.997D
• Wikidata: Q72518409
• Mol file: 420-99-5.mol

Synonyms:1-Chloro-2,2-difluoropropane;420-99-5;2,2-Difluoropropyl chloride;Propane, 1-chloro-2,2-difluoro-;1-chloro-2,2-difluoro-propane;HCFC-262ca;C3H5ClF2;2-Fluoro-1,2-dichloropropane;SCHEMBL1996000;AMY6016;DTXSID40194811;MFCD03792693;AKOS005063321;LS-119660;FT-0645629;J-504495

Chemical Property of 1-Chloro-2,2-difluoropropane

Chemical Property:

• Vapor Pressure: 68.2mmHg at 25°C
• Melting Point: -56 °C
• Refractive Index: 1.3495
• Boiling Point: 51.2 °C at 760 mmHg
• Flash Point: -22.714 °C
• PSA: 0.00000
• Density: 1.141 g/cm³
• LogP: 1.88040
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 114.0047842
• Heavy Atom Count: 6
• Complexity: 44.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2-DifluoropropylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCl)(F)F
• Uses: Halogenated hydrocarbons with anesthetic potencies.

Technology Process of 1-Chloro-2,2-difluoropropane

There total 9 articles about 1-Chloro-2,2-difluoropropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-fluoro-1,3-dichloropropane (816-38-6) → 1-chloro-2,2-difluoropropane (420-99-5) + 1,2,3-trifluoropropane (66794-36-3)

Guidance literature:

With bromine trifluoride; tin(IV) chloride; In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 20 - 25 ℃;

Reference yield:

2,3-Dichloroprop-1-ene (78-88-6) → 1-chloro-2,2-difluoropropane (420-99-5) + 1,2,2-trichloropropane (3175-23-3) + 1,2-dichloro-2-fluoro-propane (420-97-3)

Guidance literature:

With hydrogen fluoride; at 50 - 60 ℃; for 12h; Further byproducts given;

DOI:10.1021/jo01014a050

Reference yield:

2,2-difluoropropane (420-45-1) → 1-chloro-2,2-difluoropropane (420-99-5) + 1,2,2-trichloropropane (3175-23-3) + 1,2-dichloro-2-fluoro-propane (420-97-3)

Guidance literature:

With hydrogenchloride; hydrogen fluoride; chlorine; at 100 ℃; for 5h; Yield given. Yields of byproduct given; stainless-steel autoclave;

upstream raw materials:

2,3-Dichloroprop-1-ene

1,2-propanediene

2,2-difluoropropane

2-fluoro-1,3-dichloropropane

Downstream raw materials:

1,1,1,3,3,3-hexachloro-2,2-difluoro-propane

1-chloro-1,2,2-trifluoropropane

3-chloro-N-(2,2-difluoro-propyl)-aniline

Refernces

• 1、 Arimura, Takashi,Kurosawa, Shigeru,Sekiya, Akira. "A New Preparative Method for 1-Chloro-2,2,3-trifluoropropane (HCFC-253ca)". . p. 35 - 36. Retrieved 2007/10/02.
• 2、 Muratov, N. N.,Omarov, V. O.,Kunshenko, B. V.,Burmakov, A. I.,Alekseeva, L. A.,Yagupol'skii, L. M.. "REACTION OF ALKANES, ETHERS AND ALIPHATIC KETONES WITH THE SF4-HF-Cl2 SYSTEM". . p. 1621 - 1626. Retrieved 2007/10/02.