Angiotensin III

Base Information

• Chemical Name: Angiotensin III
• CAS No.: 13602-53-4
• Molecular Formula: C₄₆H₆₆N₁₂O₉
• Molecular Weight: 931.105
• Nikkaji Number: J277.812B
• Metabolomics Workbench ID: 37562
• ChEMBL ID: CHEMBL1702539
• Mol file: 13602-53-4.mol

Synonyms:Angiotensin II, Des-Asp;Angiotensin III;Des Asp Angiotensin II;Des Aspartyl Angiotensin II;Des-Asp Angiotensin II;Des-Aspartyl-Angiotensin II

Chemical Property of Angiotensin III

Chemical Property:

• Refractive Index: 1.657
• PKA: 3.56±0.10(Predicted)
• PSA: 339.94000
• Density: 1.39 g/cm³
• LogP: 3.71910
• Storage Temp.: −20°C
• Solubility.: H2O: 1.0 mg/mL, clear, colorless
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 11
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 25
• Exact Mass: 930.50757173
• Heavy Atom Count: 67
• Complexity: 1680

Purity/Quality:

98%Min ^*data from raw suppliers

AngiotensinIII,human,mouse 99.80% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N
• Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)N
• Description: Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT1) and AT2 receptors, with a 30-fold higher affinity for AT2 compared with AT1 in HEK293 cells. Ang III is the preferred agonist for renal AT2 receptors, which are responsible for sodium excretion into the urine. Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo. In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.

Technology Process of Angiotensin III

There total 2 articles about Angiotensin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

angiotensin II (4474-91-3) → L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + angiotensin III (13602-53-4,32738-16-2,82043-65-0)

Guidance literature:

With aspartyl aminopeptidase; water; In dimethyl sulfoxide; Enzymatic reaction;

DOI:10.1124/mol.114.093070

Reference yield:

→ Angiotensin III (13602-53-4,32738-16-2,82043-65-0)

Guidance literature:

Peptidsynthese nach Merrifield;

DOI:10.1021/jm00248a022

Reference yield: 74.0%

angiotensin III (13602-53-4,32738-16-2,82043-65-0) + (S)-2-Acetylamino-N-[(S)-1-((S)-4-methyl-5-oxo-4,5-dihydro-oxazol-2-yl)-ethyl]-propionamide (157596-60-6) → N-Ac-Ala-Ala-Ala-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Guidance literature:

With ethylenediaminetetraacetic acid; DL-dithiothreitol; ml papain; In N,N-dimethyl-formamide; at 24 ℃; for 1.33333h; pH=8.5;

DOI:10.1016/0040-4039(94)85208-1

upstream raw materials:

angiotensin II

Refernces

• 1、 Paiva,Goissis,Juliano,Miyamoto,Paiva. "Angiotensin-like and antagonistic activities of N-terminal modified (8-leucine)angiotensin II peptides.". . p. 239 - 241. Retrieved 2007/10/04.