3,4-Methylenedioxy-N-ethylamphetamine

Base Information

• Chemical Name: 3,4-Methylenedioxy-N-ethylamphetamine
• CAS No.: 82801-81-8
• Deprecated CAS: 14089-52-2,116861-63-3
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• European Community (EC) Number: 804-304-1
• UNII: ML1I4KK67B
• DSSTox Substance ID: DTXSID70860971
• Nikkaji Number: J1.191.663E,J263.855J
• Wikipedia: 3,4-Methylenedioxy-N-ethylamphetamine
• Wikidata: Q223011
• Metabolomics Workbench ID: 146214
• ChEMBL ID: CHEMBL126279
• Mol file: 82801-81-8.mol

Synonyms:(+--)-N-ethyl-alpha-methyl-3,4-(methylenedioxy)phenethylamine;(R)-3,4-methylenedioxyethylamphetamine;(R)-isomer of 3,4-methylenedioxyethamphetamine;(R)-methylenedioxyethylamphetamine;(R,S)-N-ethyl-3,4-methylenedioxyamphetamine;(S)-3,4-methylenedioxyethylamphetamine;(S)-isomer of 3,4-methylenedioxyethamphetamine;(S)-methylenedioxyethylamphetamine;1,3-benzodioxole-5-ethanamine, N-ethyl-alpha-methyl-;1,3-benzodioxole-5-ethanamine, N-ethyl-alpha-methyl-, hydrochloride (1:1);3,4-methylenedioxyethamphetamine;3,4-methylenedioxyethylamphetamine;3,4-methylenedioxyethylamphetamine hydrochloride;D-3,4-methylenedioxyethylamphetamine;EVE (amphetamine);HCl of 3,4-methylenedioxyethamphetamine;MDE (-)-;MDE hydrochloride;MDE, (+)-;MDEA;MDEA hydrochloride;methylenedioxyethamphetamine;methylenedioxyethamphetamine hydrochloride;N-ethyl-3,4-methylenedioxyamphetamine;N-ethyl-MDA;N-MDE

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 3,4-Methylenedioxy-N-ethylamphetamine

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.00117mmHg at 25°C
• Melting Point: 140-145 °C
• Refractive Index: 1.53
• Boiling Point: 299.8 °C at 760 mmHg
• PKA: 10.34±0.19(Predicted)
• Flash Point: 122.1 °C
• PSA: 30.49000
• Density: 1.078 g/cm³
• LogP: 2.34670
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 207.125928785
• Heavy Atom Count: 15
• Complexity: 198

Purity/Quality:

Safty Information:

• Pictogram(s): Human systemic effects.
• Hazard Codes: Xi,T,F
• Statements: 36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCNC(C)CC1=CC2=C(C=C1)OCO2
• Uses: Methylenedioxyethamphetamine is a illegal psychoactive substance.

Technology Process of 3,4-Methylenedioxy-N-ethylamphetamine

There total 6 articles about 3,4-Methylenedioxy-N-ethylamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) + ethylamine (75-04-7,85404-22-4) → 3,4-methylenedioxyethylamphetamine (14089-52-2,82801-81-8,114612-26-9,114612-27-0)

Guidance literature:

With sodium cyanoborohydride;

Reference yield:

3,4-methylenedioxyamphetamine (4764-17-4) → 3,4-methylenedioxyethylamphetamine (14089-52-2,82801-81-8,114612-26-9,114612-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / pyridine / 18 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 72 h / Heating

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/jps.2600690220

Reference yield:

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) → 3,4-methylenedioxyethylamphetamine (14089-52-2,82801-81-8,114612-26-9,114612-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₃CN / methanol / 36 h / Ambient temperature; neutral pH

2: 58 percent / pyridine / 18 h / Ambient temperature

3: LiAlH₄ / tetrahydrofuran / 72 h / Heating

With pyridine; lithium aluminium tetrahydride; sodium cyanoborohydride; In tetrahydrofuran; methanol;

DOI:10.1002/jps.2600690220

upstream raw materials:

1-(1,3-benzodioxol-5-yl)-2-propanone

ethanamine hydrochloride

ethylamine

N-[1-methyl-2-(3,4-methylenedioxyphenyl)ethyl]acetamide

Downstream raw materials:

3,4-methylenedioxyamphetamine

Refernces

• 1、 Braun,Shulgin,Braun. "Research on the central activity and analgesia of N-substituted analogs of the amphetamine derivative 3,4-methylenedioxyphenylisopropylamine". . p. 825 - 830. Retrieved 2007/10/02.