1,2-Bis(chlorodimethylsilyl)ethane

Base Information Edit

Chemical Name:1,2-Bis(chlorodimethylsilyl)ethane
CAS No.:13528-93-3
Molecular Formula:C6H16Cl2Si2
Molecular Weight:215.27
Hs Code.:29319000
European Community (EC) Number:236-871-0
UNII:B4OCJ0E6J1
DSSTox Substance ID:DTXSID9065520
Nikkaji Number:J241.167I
Wikidata:Q27274366
Mol file:13528-93-3.mol

Synonyms:1,2-Bis(chlorodimethylsilyl)ethane;13528-93-3;Ethylenebis(chlorodimethylsilane);chloro[2-(chlorodimethylsilyl)ethyl]dimethylsilane;Silane, 1,2-ethanediylbis[chlorodimethyl-;chloro-[2-[chloro(dimethyl)silyl]ethyl]-dimethylsilane;2,5-Dichloro-2,5-dimethyl-2,5-disilahexane;1,1,4,4-Tetramethyl-1,4-dichlorodisilethylene;1,1,4,4-tetramethyl-1,4-dichloro-disylethylene;C6H16Cl2Si2;UNII-B4OCJ0E6J1;B4OCJ0E6J1;EINECS 236-871-0;Silane, 1,1'-(1,2-ethanediyl)bis(1-chloro-1,1-dimethyl-;Silane, 1,2-ethanediylbis(chlorodimethyl-;ETHYLENEBIS[CHLORODIMETHYLSILANE];1,2-Bis(dimethylchlorosilyl)ethane;2,5-Dimethyl-2,5-dichloro-2,5-disilahexane;Ethylenebis[chlorodimethylsilane];LS 7080;MFCD00000505;1,1,4,4-Tetramethyl-1,4-dichloro-disilethylene;SCHEMBL149083;C6-H16-Cl2-Si2;DTXSID9065520;VGQOKOYKFDUPPJ-UHFFFAOYSA-;1,2-bis(dimethylchlorosilyl)ethane;1,2-bis(chlorodimethylsilyl) ethane;1,2-Bis-(chlorodimethylsilyl)ethane;CT2015;1,2-Bis-(chloro-dimethylsilyl)ethane;AKOS015904032;LS-7080;SB40652;1,1,4,4-Tetramethyldichlorodisilethylene;AS-52655;1,2-Bis(chlorodimethylsilyl)ethane, 96%;1,2-bis-(chloro-dimethyl-silanyl)-ethane;Silane, 1,2-ethanediylbis*chlorodimethyl-;B1688;CS-0016052;FT-0606302;EN300-84940;P15457;S01325;1,2-BIS(CHLORODIMETHYLSILYL)ETHANE [MI];A806913;J-006675;2,5-DIMETHYL-2,5-DICHLORO-2,5-DISILAHEXANE;chloro-[2-(chloro-dimethylsilyl)ethyl]-dimethylsilane;Q27274366;2-AMINO-1-BENZO[1,3]DIOXOL-5-YL-ETHANONEOXIME;Chloro(2-[chloro(dimethyl)silyl]ethyl)dimethylsilane #;F0001-0458;4-(2-acetamidopropanoylamino)-5-[[1-[[2-[[2-[[1-[[2-amino-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-5-oxo-pentanoic acid

Suppliers and Price of 1,2-Bis(chlorodimethylsilyl)ethane

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethylenebis[chlorodimethylsilane]
25g
$ 165.00

TCI Chemical
1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines] >95.0%(GC)
25g
$ 134.00

TCI Chemical
1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines] >95.0%(GC)
5g
$ 48.00

Sigma-Aldrich
1,2-Bis(chlorodimethylsilyl)ethane 96%
25g
$ 82.30

Matrix Scientific
1,2-Bis(chlorodimethylsilyl)ethane 95%+
2.500g
$ 215.00

Matrix Scientific
1,2-Bis(chlorodimethylsilyl)ethane 95%+
1g
$ 101.00

Matrix Scientific
1,2-Bis(chlorodimethylsilyl)ethane 95%+
5g
$ 323.00

Crysdot
1,2-Bis(chlorodimethylsilyl)ethane 95+%
500g
$ 367.00

ChemScene
1,2-Bis(chlorodimethylsilyl)ethane
25g
$ 60.00

Biosynth Carbosynth
1,2-Bis(chlorodimethylsilyl)ethane
25 g
$ 98.00

Total 73 raw suppliers

Chemical Property of 1,2-Bis(chlorodimethylsilyl)ethane Edit

Chemical Property:

Appearance/Colour:transparent low melting solid
Vapor Pressure:0.512mmHg at 25°C
Melting Point:35-38 °C(lit.)
Refractive Index:1.427
Boiling Point:198.24 °C at 760 mmHg
Flash Point:68.737 °C
PSA：0.00000
Density:0.97 g/cm³
LogP:3.87420
Storage Temp.:Flammables area
Sensitive.:Moisture Sensitive
Water Solubility.:Reacts with water.
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:3
Exact Mass:214.0167590
Heavy Atom Count:10
Complexity:98.3

Purity/Quality:

99% ^*data from raw suppliers

Ethylenebis[chlorodimethylsilane] ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C
Statements: 34-10
Safety Statements: 26-28-36/37/39-45-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C[Si](C)(CC[Si](C)(C)Cl)Cl
Physical properties mp 36–41°C; bp 198°C/734 mmHg.
Uses 1,2-Bis(chlorodimethylsilyl)ethane is used as Protecting Reagent for Primary Amines. It is also used in Medicine field, electronics industry and polymer material. 1,2-Bis(chlorodimethylsilyl)ethane can be used as a reagent for the protection of primary amines as their tetramethyldisilylazacyclopentane or Stabase adducts; used in combination with zinc to form organozinc carbenoids; electrophilic silylating reagent.Protection of Primary Amines.Few protecting groups exist for the N,N-diprotection of primary amines. The tetramethyldisilylazacyclopentane or Stabase adduct (3) is particularly attractive for this purpose due to its ease of preparation, base stability and facile removal. This cyclic disilane is easily prepared (eq 1) from the commercially available title reagent (1).For primary amines with pKa values between 10 and 11, typical reaction conditions involve the treatment of a dichloromethane solution of the amine with (1) in the presence of two equivalents of triethylamine at room temperature. Subsequent workup with aqueous dihydrogen phosphate provides (3) in excellent yields.1 Stabase adducts are quite stable to strongly basic conditions such as n-butyllithium and s-butyllithium (at ?25°C), lithium diisopropylamide, and Grignard reagents making it a superb candidate for use in the alkylation of substrates bearing a primary amine. For example, protected amino acid derivatives are easily alkylated (eq 2).After formation of the lithium enolate of the protected ethyl glycinate (4) under standard conditions, exposure to various alkyl halides or aldehydes yields alkylation products such as (5).

Technology Process of 1,2-Bis(chlorodimethylsilyl)ethane

There total 14 articles about 1,2-Bis(chlorodimethylsilyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%