2-Aminoindan

Base Information

• Chemical Name: 2-Aminoindan
• CAS No.: 2975-41-9
• Molecular Formula: C9H11N
• Molecular Weight: 133.193
• Hs Code.: 2921499090
• European Community (EC) Number: 221-021-3
• UNII: 1P810SQ3EY
• DSSTox Substance ID: DTXSID40183902
• Nikkaji Number: J80.606D
• Wikipedia: 2-Aminoindane
• Wikidata: Q4596856
• ChEMBL ID: CHEMBL1188176
• Mol file: 2975-41-9.mol

Synonyms:2-aminoindan;2-aminoindan hydrochloride;2-aminoindane

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2-Aminoindan

Chemical Property:

• Melting Point: 33-34 °C
• Refractive Index: n20/D 1.561(lit.)
• Boiling Point: 226.2 °C at 760 mmHg
• PKA: 9.21±0.20(Predicted)
• Flash Point: 96.8 °C
• PSA: 26.02000
• Density: 1.056 g/cm³
• LogP: 1.81280
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 133.089149355
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

Safty Information:

• Pictogram(s): Xi, C, Xn
• Hazard Codes: Xi,C,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CC2=CC=CC=C21)N
• Uses: 2-Aminoindan is an analgesic with sympathomimetic activity. 2-Aminoindan is an inhibitor norepinephrine methyltransferase. 2-Aminoindan is an analgesic with sympathomimetic activity, It is an inhibitor norepinephrine methyltransferase.

Technology Process of 2-Aminoindan

There total 25 articles about 2-Aminoindan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-indanone (615-13-4) → 2,3-dihydro-1H-inden-2-amine (2975-41-9)

Guidance literature:

With ammonium formate; C₂₅H₃₁ClIrN₂OP; at 50 ℃; for 18h; Sealed tube;

DOI:10.1002/chem.202005508

Reference yield: 90.4%

2-bromoindane (17623-96-0) → 2,3-dihydro-1H-inden-2-amine (2975-41-9)

Guidance literature:

2-bromoindane; With potassium phtalimide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

With hydrazine hydrate; In ethanol; at 50 ℃; for 2h;

With hydrogenchloride; In water; for 0.5h;

Reference yield: 79.0%

1-indene (95-13-6) → 2,3-dihydro-1H-inden-2-amine (2975-41-9)

Guidance literature:

With benzene-1,3-dicarbonitrile; 1,2,4-triphenylbenzene; ammonia; In water; acetonitrile; at 20 ℃; Irradiation;

DOI:10.1021/jo030053+

upstream raw materials:

2-amino-3H-indene-1-carbonitrile

indano<1,2-b>aziridine

indan-2-one oxime

2-nitro-2,3-dihydro-1H-inden-1-one

Downstream raw materials:

2-(2,3-dihydro-1H-inden-2-ylamino)-1-phenylethanol

2-(2,3-dihydro-1H-inden-2-ylamino)-2-phenylethanol

1-(2,3-dihydro-1H-inden-2-ylamino)-3-phenoxypropan-2-ol

3,3'-(2,3-dihydro-1H-inden-2-ylazanediyl)bis(1-phenoxypropan-2-ol)

Refernces

• 1、 Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei. "Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination". supporting information. p. 9875 - 9880. Retrieved 2021/03/29.
• 2、 -. "Preparation method of indan-2-amine". Paragraph 0028-0033. . Retrieved 2019/10/01.