2-FLUOROBENZHYDRAZIDE

Base Information

• Chemical Name: 2-FLUOROBENZHYDRAZIDE
• CAS No.: 446-24-2
• Molecular Formula: C7H7FN2O
• Molecular Weight: 154.144
• Hs Code.: 2928000090
• Mol file: 446-24-2.mol

Synonyms:Benzoicacid, o-fluoro-, hydrazide (8CI);2-(Fluorobenzoyl)hydrazine;2-Fluorobenzhydrazide;2-Fluorobenzohydrazide;2-Fluorobenzoic acid hydrazide;2-Fluorobenzoic hydrazide;2-Fluorobenzoyl hydrazide;NSC 522532;o-Fluorobenzoic acid hydrazide;

Chemical Property of 2-FLUOROBENZHYDRAZIDE

Chemical Property:

• Vapor Pressure: 0.000282mmHg at 25°C
• Melting Point: 70-74 °C
• Refractive Index: 1.552
• Boiling Point: 309.1 °C at 760 mmHg
• Flash Point: 140.7 °C
• PSA: 55.12000
• Density: 1.272 g/cm³
• LogP: 1.52040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluorobenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROBENZHYDRAZIDE

There total 9 articles about 2-FLUOROBENZHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 2-fluorobenzoate (394-35-4) → 2-fluorobezohydrazide (446-24-2)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating; Reflux;

Reference yield: 94.0%

2-fluoro-benzoic acid ethyl ester (443-26-5) → 2-fluorobezohydrazide (446-24-2)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Reflux;

DOI:10.1016/j.bmc.2015.06.051

Reference yield: 94.0%

o-fluoro-benzoic acid (445-29-4) → 2-fluorobezohydrazide (446-24-2)

Guidance literature:

o-fluoro-benzoic acid; With sulfuric acid; In ethanol; for 6h; Reflux;

With hydrazine hydrate; sodium hydrogencarbonate; acetic acid; Reflux;

DOI:10.1016/j.ejmech.2017.06.036

upstream raw materials:

2-fluoro-benzoic acid ethyl ester

2-fluorobenzamide

1-(2-fluorobenzoyl)-2-methylthio-2-imidazoline

o-fluoro-benzoic acid

Downstream raw materials:

N-benzenesulfonyl-N'-(2-fluoro-benzoyl)-hydrazine

6-chloro-3-(2-fluorophenyl)-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazine

N-2-fluorobenzoyl-N'-(2,2,2-trichloroethylidene)hydrazine

C₈H₆FN₂OS₂^(1-)*K⁽¹⁺⁾

Refernces

• 1、 Bai, Li-Ping,Guo, Yong,Jiang, Zhi-Hong,Liu, Jia-Zheng,Meng, Jie-Ru,Xu, Ting,Zheng, Zhi-Yuan. "Synthesis and biological evaluation of honokiol derivatives bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3h)-ones as potential viral entry inhibitors against sars-cov-2". . . Retrieved 2021/09/08.
• 2、 Bai, Hangyu,Jiang, Weiqi,Li, Qi,Li, Tian,Ma, Shichuang,Shi, Baojun,Wu, Wenjun. "Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles". . p. 11572 - 11581. Retrieved 2021/10/12.