2-Bromo-4-fluorophenacyl bromide

Base Information

• Chemical Name: 2-Bromo-4-fluorophenacyl bromide
• CAS No.: 594810-90-9
• Molecular Formula: C₈H₅Br₂FO
• Molecular Weight: 295.934
• Hs Code.: 2914790090
• Mol file: 594810-90-9.mol

Synonyms:2-Bromo-1-(2-bromo-4-fluorophenyl)ethan-1-one;2-Bromo-4-fluorophenacyl bromide;PC6831;2,2'-Dibromo-4-fluoroacetophenone;

Chemical Property of 2-Bromo-4-fluorophenacyl bromide

Chemical Property:

• PSA: 17.07000
• LogP: 3.16580

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-4-fluorophenacyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-fluorophenacyl bromide

There total 3 articles about 2-Bromo-4-fluorophenacyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(2-bromo-4-fluorophenyl)ethanone (1006-39-9) → 2-bromo-1-(2-bromo-4-fluorophenyl)ethan-1-one (594810-90-9)

Guidance literature:

With phenyltrimethylammonium tribromide; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield: 63.0%

→ 2-bromo-1-(2-bromo-4-fluorophenyl)ethan-1-one (594810-90-9)

Guidance literature:

Reference yield:

1-(2-bromo-4-fluorophenyl)ethanone (1006-39-9) → 2-bromo-1-(2-bromo-4-fluorophenyl)ethan-1-one (594810-90-9) + C8H4Br3FO

Guidance literature:

With bromine on polymer support; In dichloromethane;

DOI:10.1021/acs.jmedchem.7b00647

upstream raw materials:

1-(2-bromo-4-fluorophenyl)ethanone

Refernces

• 1、 Joncour, Agnès,Desroy, Nicolas,Housseman, Christopher,Bock, Xavier,Bienvenu, Natacha,Cherel, La?titia,Labeguere, Virginie,Peixoto, Christophe,Annoot, Denis,Lepissier, Luce,Heiermann, J?rg,Hengeveld, Willem Jan,Pilzak, Gregor,Monjardet, Alain,Wakselman, Emanuelle,Roncoroni, Veronique,Le Tallec, Sandrine,Galien, René,David, Christelle,Vandervoort, Nele,Christophe, Thierry,Conrath, Katja,Jans, Mia,Wohlkonig, Alexandre,Soror, Sameh,Steyaert, Jan,Touitou, Robert,Fleury, Damien,Vercheval, Lionel,Mollat, Patrick,Triballeau, Nicolas,Van Der Aar, Ellen,Brys, Reginald,Heckmann, Bertrand. "Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors". . p. 7371 - 7392. Retrieved 2017/09/23.
• 2、 -. "BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM". Page/Page column 36. . Retrieved 2008/06/13.